The influence of antidotal treatment of low-level tabun exposure on cognitive functions in rats using a water maze
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
16464751
DOI
10.1007/bf03033306
Knihovny.cz E-resources
- MeSH
- Muscarinic Antagonists pharmacology MeSH
- Antidotes pharmacology MeSH
- Atropine pharmacology MeSH
- Maze Learning drug effects MeSH
- Time Factors MeSH
- Behavior, Animal MeSH
- Cognition drug effects MeSH
- Rats MeSH
- Drug Interactions MeSH
- Organophosphates pharmacology MeSH
- Oximes pharmacology MeSH
- Rats, Wistar MeSH
- Pyridinium Compounds pharmacology MeSH
- Reaction Time drug effects MeSH
- Trimedoxime pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide MeSH Browser
- Muscarinic Antagonists MeSH
- Antidotes MeSH
- Atropine MeSH
- Organophosphates MeSH
- Oximes MeSH
- Pyridinium Compounds MeSH
- tabun MeSH Browser
- Trimedoxime MeSH
In this study, the influence of antidotal treatment of tabun poisoning on cognitive function, in the case of low-level tabun exposure, was studied. The impairment of cognitive function was evaluated by the measurement of spatial learning and memory in rats poisoned with a sublethal dose of tabun and treated with atropine alone or in combination with newly developed oximes {K027 [1-(4-hydroxyiminomethyl- pyridinium)-3-(4-carbamoylpyridinium) propane dibromide] and K048 [1-(4-hydroxyimino- methylpyridinium)-3-(4-carbamoylpyridinium) butane dibromide]} or currently available oxime (trimedoxime), using the Morris water maze. While atropine alone caused an impairment of studied cognitive functions, the addition of an oxime to atropine contributes to the improvement of cognitive performance of treated tabun-poisoned rats regardless of the type of oxime. The differences in the ameliorative effects of oximes on atropine-induced mnemonic deficits were not significant. Therefore, each low-level nerve agent exposure should be treated by complex antidotal treatment consisting of anticholinergic drug and oxime.
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