The influence of antidotal treatment of low-level tabun exposure on cognitive functions in rats using a water maze
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
16464751
DOI
10.1007/bf03033306
Knihovny.cz E-zdroje
- MeSH
- antagonisté muskarinových receptorů farmakologie MeSH
- antidota farmakologie MeSH
- atropin farmakologie MeSH
- bludiště - učení účinky léků MeSH
- časové faktory MeSH
- chování zvířat MeSH
- kognice účinky léků MeSH
- krysa rodu Rattus MeSH
- lékové interakce MeSH
- organofosfáty farmakologie MeSH
- oximy farmakologie MeSH
- potkani Wistar MeSH
- pyridinové sloučeniny farmakologie MeSH
- reakční čas účinky léků MeSH
- trimedoxim farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide MeSH Prohlížeč
- antagonisté muskarinových receptorů MeSH
- antidota MeSH
- atropin MeSH
- organofosfáty MeSH
- oximy MeSH
- pyridinové sloučeniny MeSH
- tabun MeSH Prohlížeč
- trimedoxim MeSH
In this study, the influence of antidotal treatment of tabun poisoning on cognitive function, in the case of low-level tabun exposure, was studied. The impairment of cognitive function was evaluated by the measurement of spatial learning and memory in rats poisoned with a sublethal dose of tabun and treated with atropine alone or in combination with newly developed oximes {K027 [1-(4-hydroxyiminomethyl- pyridinium)-3-(4-carbamoylpyridinium) propane dibromide] and K048 [1-(4-hydroxyimino- methylpyridinium)-3-(4-carbamoylpyridinium) butane dibromide]} or currently available oxime (trimedoxime), using the Morris water maze. While atropine alone caused an impairment of studied cognitive functions, the addition of an oxime to atropine contributes to the improvement of cognitive performance of treated tabun-poisoned rats regardless of the type of oxime. The differences in the ameliorative effects of oximes on atropine-induced mnemonic deficits were not significant. Therefore, each low-level nerve agent exposure should be treated by complex antidotal treatment consisting of anticholinergic drug and oxime.
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