Department of Toxicology Faculty of Military Health Sciences Třebešská 1575 500 01 Hradec Kralove Czech Republic

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Bajgar J. Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis and treatment. Adv Clin Chem. 2004;38:151–216. PubMed

Bajgar J, Fusek J, Jun D, Kuca K, Bartosova L. Possibility of pharmacological prophylaxis against highly toxic organophosphates. Chem Listy. 2007a;101:81–83.

Bajgar J, Hajek P, Karasova J, Slizova D, Krs O, Kuca K, Jun D, Fusek J, Capek L. Inhibition of acetylcholinesterase in different structures of the rat brain following soman intoxication pretreated with Huperzine A. Int J Mol Sci. 2007b;8:1165–1176.

Bajgar J, Bartosova L, Kuca K, Jun D, Fusek J. Changes in cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase. Drug Chem Toxicol. 2007c;30:351–359. PubMed

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Doctor BP, Maxwell DM, Saxena A. Preparation and characterization of bioscavengers for possible use against organophosphate toxicity; m-CB Medical Treatment Symposium; 1997. May 26–30, 1997, Hradec Kralove. Abstracts p. 17–18.

Dohnal V, Kuca K, Jun D. Prediction of a new broad-spectrum reactivator capable to reactivate acetylcholinesterase inhibited by nerve agents. J Appl Biomed. 2005;3:139–145.

Ekström F, Akfur C, Tunemalm AK, Lundberg S. Structural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase. Biochemistry. 2006;45:74–81. PubMed

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Fusek J, Bajgar J, Merka V. Prophylaxe von Vergiftungen mit Nervenkampfstoffen Ergebnisse einer Klinischen Studie. Koord. Sanitatsdienst. 2006;24:48–53.

Fusek J, Bajgar J, Merka V. Medikamntose Prophylaxe bei Vergiftungen mit Nervenkampfstoffen. Koord. Sanitatsdienst. 2007;25:41–47.

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Gordon RK, Haigh JR, Garcia GE, Feaster SR, Riel MA, Lenz DE. Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex in vivo exposure to soman. Chem- Biol Interact. 2005;157:239–246. PubMed

Kassa J, Vachek J, Bajgar J, Fusek J. A combination of pyridostigmine with anticholinergic drugs: effective pharmacological pretreatment of soman-poisoned mice. ASA Newslett. 2001;84:16–19.

Kassa J, Karasova J, Musilek K, Kuca K. An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology. 2008;243:311–316. PubMed

Kuca K, Kassa J. A comparison of the ability of a new bispyridinium oxime – 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. J Enzym Inhib Med Chem. 2003;8:529–535. PubMed

Kuca K, Bielavsky J, Cabal J, Kassa J. Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase. Bioorg Med Chem Lett. 2003;13:3545–3547. PubMed

Kuca K, Cabal J, Musilek K, Jun D, Bajgar J. Effective bisquaternary reactivators of tabun-inhibited AChE. J Appl Toxicol. 2005;25:491–495. PubMed

Kuca K, Jun D, Musilek K. Structural requirements of acetylcholinesterase reactivators. Mini Rev Med Chem. 2006;6:269–277. PubMed

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Musilek K, Kuca K, Jun D, Dolezal M. Synthesis of bispyridinium compounds bearing propane linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase. Lett Org Chem. 2006;3:831–835. PubMed

Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M. Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker – Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Bioorg Med Chem Lett. 2007a;17:3172–3176. PubMed

Musilek K, Holas O, Jun D, Dohnal V, Gunn-Moore F, Opletalova V, Dolezal M, Kuca K. Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker – Preparation and reactivation of tabun and paraoxon-inhibited acetylcholinesterase. Bioorg Med Chem. 2007b;15:6733–6741. PubMed

Musilek K, Jun D, Cabal J, Kassa J, Gunn-Moore F, Kuca K. Design of a potent reactivator of tabun-inhibited acetylcholinesterase – synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203) J Med Chem. 2007c;50:5514–5518. PubMed

Patocka J, Jun D, Bajgar J, Kuca K. Prophylaxis against nerve agent intoxication. Def Sci J. 2006;56:775–784.

Saxena A, Doctor BP, Sun W, Luo C, Bansal R, Naik RS, et al. HuBChE: A bioscavanger for protection against organophosphate chemical warfare agents. US Army Med Dep J. 2004;7:22–29.

Sevelova L, Bajgar J, Saxena A, Doctor BP. Protective effect of equine butyrylcholinesterase in inhalation intoxication of rats with sarin: determination of blood and brain cholinesterase activities. Inhal Toxicol. 2004;16:531–536. PubMed

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