Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
17934924
DOI
10.1080/01480540701522395
PII: 782954083
Knihovny.cz E-zdroje
- MeSH
- acetylcholinesterasa * krev metabolismus MeSH
- butyrylcholinesterasa * aplikace a dávkování krev terapeutické užití MeSH
- chemické bojové látky toxicita MeSH
- inhalační expozice MeSH
- krysa rodu Rattus MeSH
- mozek účinky léků enzymologie MeSH
- ochranné látky * aplikace a dávkování terapeutické užití MeSH
- potkani Wistar MeSH
- sarin toxicita MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- acetylcholinesterasa * MeSH
- butyrylcholinesterasa * MeSH
- chemické bojové látky MeSH
- ochranné látky * MeSH
- sarin MeSH
After sarin inhalation exposure of rats pretreated with equine serum butyrylcholinesterase (EqBuChE), cholinesterase activities of the whole blood, acetylcholinesterase (AChE) in erythrocytes, pontomedullar area, frontal cortex, and striatum of the brain, and plasma butyrylcholinesterase (BuChE) were determined. Using different doses of EqBuChE as a pretreatment (intraperitoneal injection), dose-dependent increases in plasma BuChE activity and no changes in the erythrocyte and brain AChE activities were demonstrated. Decreases in plasma BuChE activity and red blood cells (RBC) and brain AChE activities were observed in control rats after sarin inhalation exposure without EqBuChE pretreatment. In rats pretreated with EqBuChE, this inhibition was lower compared with control animals not only in the blood but also in the brain structures studied. These results demonstrate protective effects of EqBuChE pretreatment in rats intoxicated with sublethal concentrations of sarin by inhalation.
Citace poskytuje Crossref.org
