Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17934924
DOI
10.1080/01480540701522395
PII: 782954083
Knihovny.cz E-resources
- MeSH
- Acetylcholinesterase * blood metabolism MeSH
- Butyrylcholinesterase * administration & dosage blood therapeutic use MeSH
- Chemical Warfare Agents toxicity MeSH
- Inhalation Exposure MeSH
- Rats MeSH
- Brain drug effects enzymology MeSH
- Protective Agents * administration & dosage therapeutic use MeSH
- Rats, Wistar MeSH
- Sarin toxicity MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acetylcholinesterase * MeSH
- Butyrylcholinesterase * MeSH
- Chemical Warfare Agents MeSH
- Protective Agents * MeSH
- Sarin MeSH
After sarin inhalation exposure of rats pretreated with equine serum butyrylcholinesterase (EqBuChE), cholinesterase activities of the whole blood, acetylcholinesterase (AChE) in erythrocytes, pontomedullar area, frontal cortex, and striatum of the brain, and plasma butyrylcholinesterase (BuChE) were determined. Using different doses of EqBuChE as a pretreatment (intraperitoneal injection), dose-dependent increases in plasma BuChE activity and no changes in the erythrocyte and brain AChE activities were demonstrated. Decreases in plasma BuChE activity and red blood cells (RBC) and brain AChE activities were observed in control rats after sarin inhalation exposure without EqBuChE pretreatment. In rats pretreated with EqBuChE, this inhibition was lower compared with control animals not only in the blood but also in the brain structures studied. These results demonstrate protective effects of EqBuChE pretreatment in rats intoxicated with sublethal concentrations of sarin by inhalation.
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