A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

DUI

D020123 MeSH Prohlížeč

CUI

M0029863

Předchozí užití

Polyenes (1976-1998)

Historická pozn.

1999; use SIROLIMUS (NM) 1980-1997

Veřejná pozn.

1999; RAPAMYCIN (now SIROLIMUS) was indexed under POLYENES 1976-1998