Sirolimus [sirolimus]
topical
395
- Terms
-
rapamycin
-
AY 22-989
I-2190A
Rapamune
Rapamycin
Persistent link
https://www.medvik.cz/link/D020123
Definition
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
- DUI
- D020123 MeSH Browser
- CUI
- M0029863
- Previous indexing
- Polyenes (1976-1998)
- History note
- 1999; use SIROLIMUS (NM) 1980-1997
- Public note
- 1999; RAPAMYCIN (now SIROLIMUS) was indexed under POLYENES 1976-1998
Allowable subheadings
- AD
- administration & dosage 131
- AE
- adverse effects 78
- AG
- agonists
- AA
- analogs & derivatives 185
- AN
- analysis
- AI
- antagonists & inhibitors 5
- BL
- blood 1
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 3
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification 1
- ME
- metabolism
- PK
- pharmacokinetics 39
- PD
- pharmacology 76
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 235
- TO
- toxicity 4
- UR
- urine
...
Occurrences in Medvik records
D
Chemicals and Drugs
D02.540.505.113
Amphidinolides
D02.540.505.450
Lucensomycin
D02.540.505.500
Miocamycin
triolimus Chemical MeSH Browser