A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).

DUI

D020522 MeSH Browser

CUI

M0328571

Previous indexing

Lymphoma, B-Cell (1992-1999); Lymphoma, Non-Hodgkin (1992-1999)

History note

2000; for LYMPHOMA, LYMPHOCYTIC, DIFFUSE, INTERMEDIATE; LYMPHOCYTIC LYMPHOMA, DIFFUSE, POORLY-DIFFERENTIATED; LYMPHOMA, CENTROCYTIC SMALL-CELL; LYMPHOMA, LYMPHOCYTIC, DIFFUSE, POORLY-DIFFERENTIATED; & LYMPHOMA, SMALL-CELL, CENTROCYTIC use LYMPHOMA, SMALL CLEAVED-CELL, DIFFUSE 1991-1999

Public note

2000; for LYMPHOMA, LYMPHOCYTIC, DIFFUSE, INTERMEDIATE; LYMPHOCYTIC LYMPHOMA, DIFFUSE, POORLY-DIFFERENTIATED; LYMPHOMA, CENTROCYTIC SMALL-CELL; LYMPHOMA, LYMPHOCYTIC, DIFFUSE, POORLY-DIFFERENTIATED; & LYMPHOMA, SMALL-CELL, CENTROCYTIC see LYMPHOMA, SMALL CLEAVED-CELL, DIFFUSE 1991-1999