Alosterický enzym, který reguluje glykolýzu a glukoneogenezi katalýzou přenosu fosfátové skupiny z ATP na fruktóza-6-fosfát za vzniku fruktóza-2,6-difosfátu, alosterického efektoru pro jinou 6-fosfofruktokinázu (fosfofruktokinázu-1). Fosfofruktokináza-2 je bifunkční: defosforylovaná forma je kináza a fosforylovaná forma je fosfatáza, která rozkládá fruktóza-2,6-difosfát za vzniku fruktóza-6-fosfátu.

An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

DUI

D025481 MeSH Prohlížeč

CUI

M0374774

Předchozí užití

Phosphofructokinase-1 (1981-2001); Phosphoric Monoester Hydrolases (1983-2001); Phosphotransferases (1981-2001)

Historická pozn.

2002; for 6-PHOSPHOFRUCTO-2-KINASE use PHOSPHOTRANSFERASES (NM) 1993-2001, use PHOSPHOTRANSFERASES, ATP (NM) 1981-1993; for FRUCTOSE-2,6-BISPHOSPATASE use PHOSPHORIC MONOESTER HYDROLASES (NM) 1983-2001; for 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE use FRUCTOSE-BISPHOSPHATASE (NM) 1990-2001, use MULTIENZYME COMPLEXES (NM) 1990-2001, use PHOSPHOFRUCTOKINASE-1 (NM) 1990-2001

Veřejná pozn.

2002; 6-PHOSPHOFRUCTO-2-KINASE was indexed under PHOSPHOTRANSFERASES (NM) 1993-2001, under PHOSPHOTRANSFERASES, ATP (NM) 1981-1993; FRUCTOSE-2,6-BISPHOSPATASE was indexed under PHOSPHORIC MONOESTER HYDROLASES (NM) 1983-2001; 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE was indexed under FRUCTOSE-BISPHOSPHATASE (NM) 1990-2001, under MULTIENZYME COMPLEXES (NM) 1990-2001, under PHOSPHOFRUCTOKINASE-1 (NM) 1990-2001