Peroxisomal Multifunctional Protein-2 [peroxisomální multifunkční protein-2]
- Terms
-
17-beta-Hydroxysteroid Dehydrogenase 4
3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
Peroxisomal Multifunctional Enzyme Type 2
A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.
- DUI
- D064029 MeSH Browser
- CUI
- M0579232
- Previous indexing
- 17-Hydroxysteroid Dehydrogenases (1997-2013); Enoyl-CoA Hydratase (1997-2013)
- History note
- 2014
- Public note
- 2014
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
HSD17B4 protein, human Chemical MeSH Browser
Hsd17b4 protein, mouse Chemical MeSH Browser
Hsd17b4 protein, rat Chemical MeSH Browser