(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)

Annotation

/biosyn /physiol permitted

DUI

D017572 MeSH Browser

CUI

M0026633

Previous indexing

Arachidonic Acids (1980-1988); Leukotrienes (1989-1993)

History note

94; was LEUKOTRIENE A (NM) 1980-93

Online note

use LEUKOTRIENE A4 (NM) to search LEUKOTRIENE A 1980-93

Public note

94; LEUKOTRIENE A was indexed under LEUKOTRIENES 1989-93 & ARACHIDONIC ACIDS 1980-88