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High performance liquid chromatography column efficiency enhancement by zero dead volume recycling and practical approach using park and recycle arrangement
M. Minarik, M. Franc, M. Minarik,
Language English Country Netherlands
Document type Journal Article
- MeSH
- Benzene Derivatives chemistry isolation & purification MeSH
- Polycyclic Compounds chemistry isolation & purification MeSH
- Countercurrent Distribution MeSH
- Recycling * MeSH
- Stereoisomerism MeSH
- Chromatography, High Pressure Liquid instrumentation methods MeSH
- Publication type
- Journal Article MeSH
A new instrumental approach to recycling HPLC is described. The concept is based on fast reintroduction of incremental peak sections back onto the separation column. The re-circulation is performed within a closed loop containing only the column and two synchronized switching valves. By having HPLC pump out of the cycle, the method minimizes peak broadening due to dead volume. As a result the efficiency is dramatically increased allowing for the most demanding analytical applications. In addition, a parking loop is employed for temporary storage of analytes from the middle section of the separated mixture prior to their recycling.
References provided by Crossref.org
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