Peroxisomal Multifunctional Protein-2 [peroxisomální multifunkční protein-2]
- Terms
-
17-beta-Hydroxysteroid Dehydrogenase 4
3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
Peroxisomal Multifunctional Enzyme Type 2
A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.
- DUI
- D064029 MeSH Browser
- CUI
- M0579232
- Previous indexing
- 17-Hydroxysteroid Dehydrogenases (1997-2013); Enoyl-CoA Hydratase (1997-2013)
- History note
- 2014
- Public note
- 2014
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AN
- analysis 0
- AI
- antagonists & inhibitors 0
- BI
- biosynthesis 0
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 0
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 0
- EC
- economics 0
- GE
- genetics 0
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 0
- ME
- metabolism 0
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0