A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS.

DUI

D025901 MeSH Browser

CUI

M0376430

Previous indexing

Carboxypeptidases (1979-2001); Lysine Carboxypeptidase (1994-2001)

History note

2015 (2002); use CARBOXYPEPTIDASE U (NM) 1994-2001 and LYSINE CARBOXYPEPTIDASE 1997-2001

Public note

2015; see CARBOXYPEPTIDASE U 2002-2014; CARBOXYPEPTIDASE U (NM) was indexed under CARBOXYPEPTIDASES 1994-2001; for ARGININE CARBOXYPEPTIDASE see LYSINE CARBOXYPEPTIDASE 1997-2001