Polyadenylation [polyadenylace]

topical
19
Persistent link   https://www.medvik.cz/link/D026723
Definition

The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.

DUI
D026723 MeSH Browser
CUI
M0378712
Previous indexing
Poly A/metabolism (1975-2001); RNA, Messenger/metabolism (1974-2001)
History note
2002
Public note
2002

Allowable subheadings

DE
drug effects
ES
ethics
GE
genetics 3
IM
immunology
PH
physiology 1
RE
radiation effects

G Phenomena and Processes
G02 Chemical Phenomena 308
G02.111 Biochemical Phenomena 370
G02.111.760 RNA Processing, Post-Transcriptional 57
G02.111.760.225 RNA 3' End Processing 2
G02.111.760.225.710 Polyadenylation 19
G03 Metabolism 1 199
G03 Metabolic Phenomena obsolete
G03.839 RNA Processing, Post-Transcriptional 57
G03.839.225 RNA 3' End Processing 2
G03.839.225.710 Polyadenylation 19
G05 Genetic Phenomena 135
G05.308 Gene Expression Regulation 1 080
G05.308.700 RNA Processing, Post-Transcriptional 57
G05.308.700.225 RNA 3' End Processing 2
G05.308.700.225.710 Polyadenylation 19

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