Sirtuins [sirtuiny]

topical
20
Terms

proteiny podobné sir2
SIRT
sirtuin

 

Silent Mating Type Information Regulator 2-like Proteins
Sir2-like Proteins
SIRT
SIRTs
Sirtuin

Persistent link   https://www.medvik.cz/link/D037761
Definition

A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.

DUI
D037761 MeSH Browser
CUI
M0413549
Previous indexing
Histone Deacetylase (2000-2002)
History note
2003
Public note
2003

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors 4
BI
biosynthesis 1
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 3
CL
classification 1
DF
deficiency
DE
drug effects 1
EC
economics
GE
genetics 6
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 11
PK
pharmacokinetics 1
PD
pharmacology 1
PH
physiology 4
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.277 Hydrolases 475
D08.811.277.087 Amidohydrolases 45
D08.811.277.087.520 Histone Deacetylases 69
D08.811.277.087.520.200 Group III Histone Deacetylases
D08.811.277.087.520.200.650 Sirtuins 20
D08.811.277.087.520.200.650.100 Sirtuin 1 29
D08.811.277.087.520.200.650.200 Sirtuin 2 3
D08.811.277.087.520.200.650.600 Sirtuin 3 5
D08.811.913 Transferases 72
D08.811.913.400 Glycosyltransferases 48
D08.811.913.400.725 Pentosyltransferases 42
D08.811.913.400.725.115 ADP Ribose Transferases 4
D08.811.913.400.725.115.180 Cholera Toxin 18
D08.811.913.400.725.115.220 Diphtheria Toxin 12
D08.811.913.400.725.115.660 NAD+ Nucleosidase 2
D08.811.913.400.725.115.680 Pertussis Toxin 28
D08.811.913.400.725.115.690 Poly(ADP-ribose) Polymerases 63
D08.811.913.400.725.115.826 Pseudomonas aeruginosa Exotoxin A 1
D08.811.913.400.725.115.961 Sirtuins 20
D08.811.913.400.725.115.961.200 Sirtuin 2 3
D08.811.913.400.725.115.961.600 Sirtuin 3 5
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.008 3',5'-Cyclic-AMP Phosphodiesterases 12
D12.776.476.009 3',5'-Cyclic-GMP Phosphodiesterases 2
D12.776.476.011 Activating Transcription Factor 6 3
D12.776.476.024 Adaptor Proteins, Signal Transducing 176
D12.776.476.050 Adenylyl Cyclases 160
D12.776.476.075 Apoptosis Regulatory Proteins 78
D12.776.476.081 Axin Signaling Complex 1
D12.776.476.156 Circadian Rhythm Signaling Peptides and Proteins 11
D12.776.476.175 Cold Shock Proteins and Peptides 3
D12.776.476.225 Cyclin-Dependent Kinase Inhibitor Proteins 42
D12.776.476.262 Cyclins 112
D12.776.476.265 Disks Large Homolog 4 Protein 1
D12.776.476.325 GTP-Binding Protein Regulators 16
D12.776.476.338 GTP-Binding Proteins 117
D12.776.476.350 Guanylate Cyclase 29
D12.776.476.381 I-kappa B Proteins 5
D12.776.476.383 Inhibitor of Growth Protein 1
D12.776.476.387 Intracellular Calcium-Sensing Proteins 2
D12.776.476.410 Mesothelin 2
D12.776.476.420 Methyl-Accepting Chemotaxis Proteins
D12.776.476.445 Mitogen-Activated Protein Kinase Phosphatases 1
D12.776.476.534 Mucin-4 5
D12.776.476.539 Myristoylated Alanine-Rich C Kinase Substrate
D12.776.476.543 Olfactory Marker Protein
D12.776.476.555 Phosphatidylethanolamine Binding Protein
D12.776.476.556 Phosphatidylinositol 3-Kinases 122
D12.776.476.557 Phosphoinositide Phospholipase C 2
D12.776.476.559 Phosphoprotein Phosphatases 23
D12.776.476.561 Protein Phosphatase Inhibitory Proteins
D12.776.476.563 Protein Serine-Threonine Kinases 271
D12.776.476.564 Protein Tyrosine Phosphatases 27
D12.776.476.568 Protein-Tyrosine Kinases 620
D12.776.476.590 PTEN Phosphohydrolase 49
D12.776.476.650 RNA-Binding Protein EWS 15
D12.776.476.700 SAP90-PSD95 Associated Proteins
D12.776.476.800 Secreted Frizzled-Related Proteins
D12.776.476.900 Sirtuins 20
D12.776.476.900.100 Sirtuin 1 29
D12.776.476.900.200 Sirtuin 2 3
D12.776.476.900.600 Sirtuin 3 5
D12.776.476.932 Tuberous Sclerosis Complex 1 Protein 7
D12.776.476.935 Tuberous Sclerosis Complex 2 Protein 9
D12.776.476.938 Tumor Necrosis Factor alpha-Induced Protein 3 1
D12.776.476.941 Tumor Protein, Translationally-Controlled 1

SIR-2.1 protein, C elegans Chemical MeSH Browser

SIRT3 protein, rat Chemical MeSH Browser

SIRT4 protein, human Chemical MeSH Browser

SIRT4 protein, mouse Chemical MeSH Browser

SIRT5 protein, human Chemical MeSH Browser

SIRT5 protein, mouse Chemical MeSH Browser

SIRT5 protein, rat Chemical MeSH Browser

SIRT6 protein, human Chemical MeSH Browser

SIRT7 protein, human Chemical MeSH Browser

SIRT7 protein, rat Chemical MeSH Browser

SRT2 protein, Arabidopsis Chemical MeSH Browser

Sir2 protein, Kluyveromyces lactis Chemical MeSH Browser

Sirt2 protein, Drosophila Chemical MeSH Browser

Sirt6 protein, mouse Chemical MeSH Browser

Sirt7 protein, mouse Chemical MeSH Browser

cobB protein, E Coli Chemical MeSH Browser

sir-2.3 protein, C elegans Chemical MeSH Browser

sirtuin 6, rat Chemical MeSH Browser

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