Histamine H1 Antagonists, Non-Sedating [nesedativní H1-antihistaminika]
- Terms
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3. generace antagonistů H1-receptoru
antihistaminika 2. generace
antihistaminika II. generace
antihistaminika III. generace
H1-antihistaminika II. generace
histamin H1 - antagonisté nesedativní
histaminové H1-receptory - blokátory nesedativní
nesedativní antagonisté histaminu H1
nesedativní antihistaminika 2. generace
nesedativní antihistaminika II. generace
nesedativní H1-antagonisté
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H1 Antihistamines, Non-Sedating
Second Generation Antihistamine
Second Generation Antihistamines
Second Generation H1 Antagonist
Second Generation H1 Antagonists
Third Generation H1 Antagonist
Third Generation H1 Antagonists
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
- DUI
- D039563 MeSH Browser
- CUI
- M0419330
- Previous indexing
- Benzhydryl Compounds (1982-2002); Histamine H1 Antagonists (1982-2002)
- History note
- 2003
- Public note
- 2003
Allowable subheadings
- AD
- administration & dosage 13
- AE
- adverse effects 8
- AN
- analysis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 1
- CL
- classification 3
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics 4
- PD
- pharmacology 16
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 33
- TO
- toxicity
- UR
- urine