11-beta-Hydroxysteroid Dehydrogenase Type 2 [11-beta-hydroxysteroiddehydrogenasa typ 2]
- Terms
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11-beta-hydroxysteroiddehydrogenáza typ 2
11-beta-hydroxysteroiddehydrogenáza typu 2
11beta-HSD2
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11 beta-HSD2
11 beta-Hydroxysteroid Dehydrogenase Type 2
11beta-HSD2
11beta-HSD2 Reductase
11beta-Hydroxysteroid Dehydrogenase Type 2
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
- DUI
- D043209 MeSH Browser
- CUI
- M0076299
- Previous indexing
- Hydroxysteroid Dehydrogenases (1992-2003)
- History note
- 2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003
- Public note
- 2004; 11 BETA-HSD2 was indexed under HYDROXYSTEROID DEHYDROGENASES 1992-2003
Combination
- deficiency
- Mineralocorticoid Excess Syndrome, Apparent
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects 1
- AN
- analysis 1
- AI
- antagonists & inhibitors 2
- BI
- biosynthesis 2
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DE
- drug effects
- EC
- economics
- GE
- genetics 4
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 7
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology 1
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
HSD11B2 protein, human Chemical MeSH Browser
HSD11B2 protein, mouse Chemical MeSH Browser
Hsd11b2 protein, rat Chemical MeSH Browser