Ubiquitin-Protein Ligase Complexes [komplexy ubikvitinligas]
- Terms
-
komplex ubiquitin ligázy
komplexy ubikvitin ligáz
komplexy ubikvitinligáz
ubikvitinproteinligasy - komplexy
Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).
- Annotation
- UBIQUITIN-PROTEIN LIGASES is also available
- k dispozici je i deskriptor UBIKVITINLIGASY
- DUI
- D043743 MeSH Browser
- CUI
- M0115796
- Previous indexing
- Ligases (1983-2003)
- History note
- 2004
- Public note
- 2004
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis 1
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 1
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 2
- HI
- history
- IM
- immunology
- IP
- isolation & purification 1
- ME
- metabolism 7
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology 4
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 3
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
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