Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).

Anotace

UBIQUITIN-PROTEIN LIGASES is also available

k dispozici je i deskriptor UBIKVITINLIGASY

DUI

D043743 MeSH Prohlížeč

CUI

M0115796

RN

EC 2.3.2.23

Předchozí užití

Ligases (1983-2003)

Historická pozn.

2004

Veřejná pozn.

2004