A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.

DUI

D044464 MeSH Browser

CUI

M0236839

Previous indexing

Receptors, Thrombin (1994-2003)

History note

2004; use RECEPTOR, PAR-2 (NM) 1994-2003; for TRYPSIN RECEPTOR use RECEPTOR, PAR-2 (NM) 1986-2003

Public note

2004; PROTEINASE ACTIVATED RECEPTOR 2 (now RECEPTOR, PAR-2) was indexed under RECEPTORS, THROMBIN 1994-2003; TRYPSIN RECEPTOR (now RECEPTOR, PAR-2) was indexed under RECEPTORS, CELL SURFACE 1986-2003