Focal Adhesion Kinase 1 [fokální adhezní kinasa 1]
- Terms
-
endogenní substrát pp120
fokální adhezní kináza 1
protein p125FAK
protein-tyrozinkináza 2
-
Endogenous Substrate pp120
Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
p125FAK Protein
Protein Tyrosine Kinase 2
A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
- DUI
- D051417 MeSH Browser
- CUI
- M0142569
- History note
- 2006(1986)
- Public note
- 2006; ENDOGENOUS SUBSTRATE PP120, FOCAL ADHESION-ASSOCIATED, PROTEIN-TYROSINE KINASE PP125FAK, & P125FAK PROTEIN were indexed under PROTEIN-TYROSINE KINASE 2001-2005, & under CELL ADHESION MOLECULES 1990-2000, & MEMBRANE GLYCOPROTEINS 1987-1992, MEMBRANE PROTEINS 1986-1987
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- AI
- antagonists & inhibitors 1
- BI
- biosynthesis 1
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency 1
- DE
- drug effects
- EC
- economics
- GE
- genetics 1
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
Fak protein, Drosophila Chemical MeSH Browser
PTK2 protein, human Chemical MeSH Browser
Ptk2 protein, mouse Chemical MeSH Browser
Ptk2 protein, rat Chemical MeSH Browser