Immunoreceptor Tyrosine-Based Activation Motif [ITAM motiv]

topical
Terms

aktivační motiv imunoreceptorů založený na tyrosinu
ITAM

 

Immune Receptor Tyrosine-Based Activation Motif
Immuno-Receptor Tyrosine-Based Activation Motif

Persistent link   https://www.medvik.cz/link/D061625
Definition

A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.

DUI
D061625 MeSH Browser
CUI
M0559749
History note
2013
Public note
2013

Allowable subheadings

DE
drug effects 0
GE
genetics 0
IM
immunology 0
PH
physiology 0
RE
radiation effects 0

G Phenomena and Processes
G01 Physical Phenomena 77
G02 Chemical Phenomena 307
G02.111 Biochemical Phenomena 370
G02.111.570 Molecular Structure 1 314
G02.111.570.820 Molecular Conformation 228
G02.111.570.820.709 Protein Conformation 556
G02.111.570.820.709.275 Protein Structural Elements 1
G02.111.570.820.709.275.500 Amino Acid Motifs 101
G02.111.570.820.709.275.500.030 Ankyrin Repeat 9
G02.111.570.820.709.275.500.050 AT-Hook Motifs 1
G02.111.570.820.709.275.500.127 Cystine Knot Motifs
G02.111.570.820.709.275.500.205 F-Box Motifs
G02.111.570.820.709.275.500.360 Helix-Loop-Helix Motifs
G02.111.570.820.709.275.500.440 Immunoreceptor Tyrosine-Based Activation Motif
G02.111.570.820.709.275.500.480 Immunoreceptor Tyrosine-Based Inhibition Motif
G02.111.570.820.709.275.500.490 Kazal Motifs
G02.111.570.820.709.275.500.500 Kelch Repeat 1
G02.111.570.820.709.275.500.520 Leucine Zippers 4
G02.111.570.820.709.275.500.695 Poly-ADP-Ribose Binding Motif
G02.111.570.820.709.275.500.869 RNA-Binding Motifs
G02.111.570.820.709.275.500.898 Sterile Alpha Motif
G02.111.570.820.709.275.500.913 AAA Domain 1
G02.111.570.820.709.275.500.920 Tetratricopeptide Repeat
G02.111.570.820.709.275.500.927 WD40 Repeats
G02.111.570.820.709.275.500.985 Zinc Fingers 28
G03 Metabolic Phenomena obsolete
G04 Cell Physiological Phenomena 514
G05 Genetic Phenomena 135
G06 Microbiological Phenomena 96
G07 Physiological Phenomena 176
G08 Reproductive and Urinary Physiological Phenomena 18
G09 Circulatory and Respiratory Physiological Phenomena 94
G10 Digestive System and Oral Physiological Phenomena 4
G11 Musculoskeletal and Neural Physiological Phenomena 16
G12 Immune System Phenomena 248
G13 Integumentary System Physiological Phenomena 14
G14 Ocular Physiological Phenomena 147
G15 Plant Physiological Phenomena 158
G16 Biological Phenomena 129
G17 Mathematical Concepts 66

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