Immunoreceptor Tyrosine-Based Inhibition Motif [ITIM motiv]

topical
Terms

imunoreceptorový tyrosinový inhibiční motiv
inhibiční motiv imunoreceptorů na bázi tyrosinu
inhibiční motiv imunoreceptorů založený na tyrosinu
ITIM

 

Immune Receptor Tyrosine-Based Inhibition Motif
Immuno-Receptor Tyrosine-Based Inhibition Motif

Persistent link   https://www.medvik.cz/link/D061626
Definition

A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.

DUI
D061626 MeSH Browser
CUI
M0559750
History note
2013
Public note
2013

Allowable subheadings

DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects

G Phenomena and Processes
G01 Physical Phenomena 79
G02 Chemical Phenomena 308
G02.111 Biochemical Phenomena 370
G02.111.570 Molecular Structure 1 332
G02.111.570.820 Molecular Conformation 228
G02.111.570.820.709 Protein Conformation 558
G02.111.570.820.709.275 Protein Structural Elements 1
G02.111.570.820.709.275.500 Amino Acid Motifs 101
G02.111.570.820.709.275.500.030 Ankyrin Repeat 9
G02.111.570.820.709.275.500.050 AT-Hook Motifs 1
G02.111.570.820.709.275.500.127 Cystine Knot Motifs
G02.111.570.820.709.275.500.205 F-Box Motifs
G02.111.570.820.709.275.500.360 Helix-Loop-Helix Motifs
G02.111.570.820.709.275.500.440 Immunoreceptor Tyrosine-Based Activation Motif
G02.111.570.820.709.275.500.480 Immunoreceptor Tyrosine-Based Inhibition Motif
G02.111.570.820.709.275.500.490 Kazal Motifs
G02.111.570.820.709.275.500.500 Kelch Repeat 1
G02.111.570.820.709.275.500.520 Leucine Zippers 4
G02.111.570.820.709.275.500.695 Poly-ADP-Ribose Binding Motif
G02.111.570.820.709.275.500.869 RNA-Binding Motifs
G02.111.570.820.709.275.500.898 Sterile Alpha Motif
G02.111.570.820.709.275.500.913 AAA Domain 1
G02.111.570.820.709.275.500.920 Tetratricopeptide Repeat
G02.111.570.820.709.275.500.927 WD40 Repeats
G02.111.570.820.709.275.500.985 Zinc Fingers 28
G03 Metabolism 1 199
G03 Metabolic Phenomena obsolete
G04 Cell Physiological Phenomena 515
G05 Genetic Phenomena 135
G06 Microbiological Phenomena 96
G07 Physiological Phenomena 176
G08 Reproductive and Urinary Physiological Phenomena 18
G09 Circulatory and Respiratory Physiological Phenomena 94
G10 Digestive System and Oral Physiological Phenomena 4
G11 Musculoskeletal and Neural Physiological Phenomena 17
G12 Immune System Phenomena 249
G13 Integumentary System Physiological Phenomena 14
G14 Ocular Physiological Phenomena 148
G15 Plant Physiological Phenomena 158
G16 Biological Phenomena 130
G17 Mathematical Concepts 66

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