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Autor
Bezak, Branislav 1 Bohm, Allan 1 Danova, Katarina 1 Farsky, Stefan 1 Hlavata, Tereza 1 Jajcay, Nikola 1 Kissova, Viera 1 Kurecko, Marian 1 Kyselovic, Jan 1 Michalek, Peter 1 Mojto, Viliam 1 Olejnik, Peter 1 Petrikova, Katarina 1 Snopek, Peter 1 Tothova, Lubomira 1 Uher, Tomas 1 Vachalcova, Marianna 1
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Pracoviště
1st Department of Cardiology East Slo... 1 1st Department of Internal Medicine F... 1 3rd Department of Internal Medicine F... 1 Department of Cardiology Faculty Hosp... 1 Department of Complex Systems Institu... 1 Department of Laboratory Medicine Nat... 1 Faculty of Medicine Comenius Universi... 1 Faculty of Medicine Pavol Jozef Safar... 1 Faculty of Medicine Slovak Medical Un... 1 House of the Heart Slovak League Agai... 1 Institute of Molecular Biomedicine Fa... 1 National Institute of Cardiovascular ... 1 Premedix Academy Bratislava Slovakia 1 St Elizabeth University of Health and... 1
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Autor
Bezak, Branislav 1 Bohm, Allan 1 Danova, Katarina 1 Farsky, Stefan 1 Hlavata, Tereza 1 Jajcay, Nikola 1 Kissova, Viera 1 Kurecko, Marian 1 Kyselovic, Jan 1 Michalek, Peter 1 Mojto, Viliam 1 Olejnik, Peter 1 Petrikova, Katarina 1 Snopek, Peter 1 Tothova, Lubomira 1 Uher, Tomas 1 Vachalcova, Marianna 1
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Pracoviště
1st Department of Cardiology East Slo... 1 1st Department of Internal Medicine F... 1 3rd Department of Internal Medicine F... 1 Department of Cardiology Faculty Hosp... 1 Department of Complex Systems Institu... 1 Department of Laboratory Medicine Nat... 1 Faculty of Medicine Comenius Universi... 1 Faculty of Medicine Pavol Jozef Safar... 1 Faculty of Medicine Slovak Medical Un... 1 House of the Heart Slovak League Agai... 1 Institute of Molecular Biomedicine Fa... 1 National Institute of Cardiovascular ... 1 Premedix Academy Bratislava Slovakia 1 St Elizabeth University of Health and... 1
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PubMed Central od 2014
Europe PubMed Central od 2014
Open Access Digital Library od 2014-01-01
Open Access Digital Library od 2014-01-01
ROAD: Directory of Open Access Scholarly Resources od 2014
PubMed
34712712
DOI
10.3389/fcvm.2021.742601
Knihovny.cz E-zdroje
Background: Atrial fibrillation (AF) is associated with high risk of stroke preventable by timely initiation of anticoagulation. Currently available screening tools based on ECG are not optimal due to inconvenience and high costs. Aim of this study was to study the diagnostic value of apelin for AF in patients with high risk of stroke. Methods: We designed a multicenter, matched-cohort study. The population consisted of three study groups: a healthy control group (34 patients) and two matched groups of 60 patients with high risk of stroke (AF and non-AF group). Apelin levels were examined from peripheral blood. Results: Apelin was significantly lower in AF group compared to non-AF group (0.694 ± 0.148 vs. 0.975 ± 0.458 ng/ml, p = 0.001) and control group (0.982 ± 0.060 ng/ml, p < 0.001), respectively. Receiver operating characteristic (ROC) analysis of apelin as a predictor of AF scored area under the curve (AUC) of 0.658. Apelin's concentration of 0.969 [ng/ml] had sensitivity = 0.966 and specificity = 0.467. Logistic regression based on manual feature selection showed that only apelin and NT-proBNP were independent predictors of AF. Logistic regression based on selection from bivariate analysis showed that only apelin was an independent predictor of AF. A logistic regression model using repeated stratified K-Fold cross-validation strategy scored an AUC of 0.725 ± 0.131. Conclusions: Our results suggest that apelin might be used to rule out AF in patients with high risk of stroke.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.