International Journal of Celiac Disease (IJCD) is an international clinical and scientific journal that aims to cover the multiple aspects of celiac disease (CD). With the renewal of the new year of 2018, the IJCD is celebrating four years of academical publications of 170 articles. The objective recognition by the medical, paramedical and the scientific community, represented by the substantial number of articles’ views, downloads, likes and citations, is indicative of a proliferative and successful journal, at least for its first four years.
- Klíčová slova
- citace, citovanost,
- MeSH
- periodika jako téma statistika a číselné údaje MeSH
Anti-tissue transglutaminase (tTg) IgA are considered the most frequently used serological marker for celiac disease diagnosis. Despite its recommended leading position by the 2012 ESPGHAN diagnostic criteria, it exposes multiple false positive and negative titers. In view of the critical opinions expressed lately in the literature against the application of those criteria, the bias in the central place occupied by tTg-IgA in the new ESPGHAN CD Diagnostic Guidelines and the emergence of newer serological marker for celiac disease, it is hoped that the revised guidelines will open up the limited, problematic and single Tg2-IgA antibody for other or additional single or combined serological diagnostic markers.
Dietitians play a pivotal role in the education, follow-up and navigation of the gluten-free diet for patients affected by celiac disease. Since gluten withdrawal is the cornerstone of celiac disease therapy, and since various future therapeutic strategies, are not yet on the market, the patients relay heavily on the registered dietitian nutritionists (RDNs) advice and service to cope with the gluten-free diet tough alley. Unfortunately, gluten withdrawal, nowadays, represent also a torrid time. The actual surge in incidence, wheat content, gluten intake, celiac disease-related T-cell stimulatory epitopes in wheat, usage in the processed food industries, nutritional deficiencies, changing phenotype and the fact that gluten is potentially detrimental to humankind health, make the RDNs role more complex, difficult and challenging. The present review expands on the gluten-free diet related tough alley in torrid time, which the registered dietitian nutritionists are facing when dealing with gluten-sensitive patients.
- MeSH
- adherence a compliance při léčbě MeSH
- bezlepková dieta * metody MeSH
- celiakie * diagnóza dietoterapie komplikace MeSH
- fyziologie výživy MeSH
- gluteny škodlivé účinky MeSH
- kontaminace potravin MeSH
- lidé MeSH
- potravinářské přísady škodlivé účinky MeSH
- pšenice genetika škodlivé účinky MeSH
- Check Tag
- lidé MeSH
Genetic and environmental risk factors for celiac disease are well established, however, the precipitating events leading to development of celiac disease and associated conditions remain enigmatic. Being a multi-faced, multi-organ disease and the multiple extra intestinal phenotypes of celiac disease, further more add to its complexity. The present editorial summarizes the potential mechanisms connecting gut eco system events to remote organ manifestations and dysfunctions in celiac disease. It is suggested that nutrients, the microbiome/dysbiome interplay, the local post translational modification of naive proteins, the leaky gut and the leaked immunogenic or toxic molecules or complexes and the circulating pro-inflammatory immune cells and cytokines are at the basis of the gutremote organ pathologies, in CD.
Genetic risk factors for autoimmune diseases are constantly discovered, however, environmental factors are laggingbehind and the precipitating events leading to development of autoimmune diseases remain enigmatic. Gluten is a well-established inducing nutrient in celiac disease and gluten withdrawal is the only current effective therapy. More and more studies have shown that non-celiac autoimmune diseases can partially respond to gluten free diet. The present editorial reviews those conditions and suggest multiple potential mechanisms that might operate in clinical amelioration of non-celiac autoimmune diseases.
Celiac disease is a multi-organ disorder which is highly variable in its clinical expression, presenting multiple enteric and extraintestinal manifestations. However, most of treating physicians and dieticians regard celiac disease as a chronic, gradually evolving, asymptomatic or hypo-symptomatic entity. The present mini-review aims to screen the literature for acute presentations of celiac disease and to increase the awareness of the medical communities, for such a possibility. It appears that the disease can present acutely in multiple symptomatic, phenotypic and laboratory pictures. The acute presentation involves mainly the gastrointestinal tract and adjacentorgans like liver and gallbladder, however, extraintestinal and remote organs presentations can occur.
- MeSH
- akutní nemoc * MeSH
- časná diagnóza MeSH
- celiakie * diagnóza patofyziologie MeSH
- lidé MeSH
- opožděná diagnóza MeSH
- Check Tag
- lidé MeSH
Several strategies have been considered for enzymatic detoxification of dietary gluten and to reduce immunogenisity of gliadin peptides. An enzymatic therapy using enterically coated tablets containing caricain (Gluteguard), originated from a papaya, on celiac disease patients challenged with gluten was reported. Glut guard was able to protect these patients from adverse symptoms being induced by gluten challenge. The advantages of the fruit originated preparation are: it does not contain living microbes or bacterial purified or engineered products. It can be considered as a preventive therapy and further step in the future therapeutical strategy race for the celiac affected population benefits.
- Klíčová slova
- caricain,
- MeSH
- bezlepková dieta MeSH
- celiakie * dietoterapie imunologie terapie MeSH
- cysteinové endopeptidasy terapeutické užití MeSH
- enzymová substituční terapie * MeSH
- lidé MeSH
- manipulace s potravinami MeSH
- rostlinné proteiny terapeutické užití MeSH
- transglutaminasy metabolismus MeSH
- vystavení vlivu životního prostředí MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- úvodní články MeSH
In the accordance of readers, we are introducing a new chapter in Journal, which will consist in interview with one people. The chapter will appear as needed and the people will be select by editorial board. Professor Michael N. Marsh was invited for first interview and you can find a message from this interview here.
- MeSH
- celiakie * MeSH
- Publikační typ
- rozhovory MeSH
The gut ecosystem with myriads of microorganisms and the high concentration of immune system cells can be considered as a separate organ on its own. The balanced interaction between the host and microbial cells has been shaped during the long co-evolutionary process. In dysbiotic conditions, however, this balance is compromised and results in abnormal interaction between the host and microbiota. Celiac disease is such an example were dysbiotic and metabolic signature are shaping the disease progression in genetically susceptible individuals. Short chain fatty acids are bacterial originated metabolic messenger between the pathobionts and the intestinal mucosa. Their local luminal effects and systemic ones were just recently unraveled. Accumulating data attribute multiple beneficial effects to them. Changes in microbiota and their short-chain fatty acids production is clearly related to the pathogenesis of celiac disease and might open new therapeutic strategies to combat the disease.
The puzzle of breast feeding effects on celiac disease development is complicated and despite numerous studies, remains unresolved. Several prospective or retrospective observational studies on the topic were reported, with contradictory results. The geoepidemiology teaches us that celiac disease incidence, in the west, is increasing, while breast feeding is decreasing, going along with the protective effect of mother’s milk. But, human milk and gluten are only two in the growing list of environmental factors that affect celiac disease induction or behavior. The recent increased knowledge on gluten side effects in non-celiac populations and the fact that human milk contains gluten peptides, further complicate the breast milk-gluten-celiac disease cross-talks. Latest studies revealed that breast feeding, whether exclusive or in combination with formula intake, did not reduce the risk of CD development. More so, recent publications concluded that timing of introduction of gluten to infant diet did not influenced the risk of development of CD. It is hypothesized that local environments, nutritional habits, intestinal ecosystems or genetic background might have influenced the published results. Much more epidemiological and prospective investigational studies might clarify the jigsaw puzzle of breast feeding and celiac disease behavior.
