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Autor
Aglago, Elom K 1 Arndt, Volker 1 Barry, Elizabeth L 1 Baurley, James W 1 Berndt, Sonja I 1 Bien, Stephanie A 1 Bishop, D Timothy 1 Bouras, Emmanouil 1 Brenner, Hermann 1 Budiarto, Arif 1 Bézieau, Stéphane 1 Campbell, Peter T 1 Carreras-Torres, Robert 1 Casey, Graham 1 Cenggoro, Tjeng Wawan 1 Chan, Andrew T 1 Chang-Claude, Jenny 1 Chanock, Stephen J 1 Chen, Xuechen 1 Conti, David V 1
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Pracoviště
BioRealm LLC Walnut CA USA 1 Bioinformatics and Data Science Resea... 1 Biostatistics Division Kaiser Permane... 1 Broad Institute of Harvard and MIT Ca... 1 CIBER Epidemiología y Salud Pública M... 1 Cancer Epidemiology Division Cancer C... 1 Center for Cancer Research Medical Un... 1 Center for Gastrointestinal Biology a... 1 Center for Precision Medicine Departm... 1 Centre for Epidemiology and Biostatis... 1 Channing Division of Network Medicine... 1 Clalit National Cancer Control Center... 1 Clinical and Translational Epidemiolo... 1 Colorectal Cancer Group ONCOBELL Prog... 1 Colorectal Cancer Group ONCOBELL Prog... 1 Computer Science Department School of... 1 Consortium for Biomedical Research in... 1 Department of Biostatistics Universit... 1 Department of Clinical Sciences Facul... 1 Department of Community Medicine and ... 1
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Autor
Aglago, Elom K 1 Arndt, Volker 1 Barry, Elizabeth L 1 Baurley, James W 1 Berndt, Sonja I 1 Bien, Stephanie A 1 Bishop, D Timothy 1 Bouras, Emmanouil 1 Brenner, Hermann 1 Budiarto, Arif 1 Bézieau, Stéphane 1 Campbell, Peter T 1 Carreras-Torres, Robert 1 Casey, Graham 1 Cenggoro, Tjeng Wawan 1 Chan, Andrew T 1 Chang-Claude, Jenny 1 Chanock, Stephen J 1 Chen, Xuechen 1 Conti, David V 1
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Pracoviště
BioRealm LLC Walnut CA USA 1 Bioinformatics and Data Science Resea... 1 Biostatistics Division Kaiser Permane... 1 Broad Institute of Harvard and MIT Ca... 1 CIBER Epidemiología y Salud Pública M... 1 Cancer Epidemiology Division Cancer C... 1 Center for Cancer Research Medical Un... 1 Center for Gastrointestinal Biology a... 1 Center for Precision Medicine Departm... 1 Centre for Epidemiology and Biostatis... 1 Channing Division of Network Medicine... 1 Clalit National Cancer Control Center... 1 Clinical and Translational Epidemiolo... 1 Colorectal Cancer Group ONCOBELL Prog... 1 Colorectal Cancer Group ONCOBELL Prog... 1 Computer Science Department School of... 1 Consortium for Biomedical Research in... 1 Department of Biostatistics Universit... 1 Department of Clinical Sciences Facul... 1 Department of Community Medicine and ... 1
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- Dimou, Niki
- Kim, Andre E
- Flanagan, Orlagh
- Murphy, Neil
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Diez-Obrero, Virginia
Autor Diez-Obrero, Virginia Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, 08908, Spain Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, 08908, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Barcelona, 08908, Spain Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, 08908, Spain
- Shcherbina, Anna
- Aglago, Elom K
- Bouras, Emmanouil
- Campbell, Peter T
- Casey, Graham
NLK
Free Medical Journals
od 1947 do Před 1 rokem
Freely Accessible Journals
od 1947 do Před 1 rokem
PubMed Central
od 1947 do Před 1 rokem
Europe PubMed Central
od 1947 do Před 1 rokem
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1947-01-01
Open Access Digital Library
od 1999-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
37365285
DOI
10.1038/s41416-023-02312-z
Knihovny.cz E-zdroje
BACKGROUND: Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis. METHODS: We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom; d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test). RESULTS: Based on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 - ORAA: 1.62, 95% CI: 1.34-1.96; ORAG: 1.41, 95% CI: 1.30-1.54; ORGG: 1.22, 95% CI: 1.13-1.31; p-value3-d.f.: 5.46 × 10-11) and 13q14.13 (rs9526201, LRCH1 - ORGG: 2.11, 95% CI: 1.56-2.83; ORGA: 1.52, 95% CI: 1.38-1.68; ORAA: 1.13, 95% CI: 1.06-1.21; p-value2-d.f.: 7.84 × 10-09). DISCUSSION: These results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.
- MeSH
- celogenomová asociační studie metody MeSH
- diabetes mellitus * genetika MeSH
- genetická predispozice k nemoci MeSH
- interakce genů a prostředí MeSH
- jednonukleotidový polymorfismus MeSH
- kolorektální nádory * genetika MeSH
- lidé MeSH
- mikrofilamentové proteiny genetika MeSH
- rizikové faktory MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
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