- Publikační typ
- abstrakt z konference MeSH
Hyperforin is a prenylated phloroglucinol derivative which occurs in the plant Hypericum perforatum L. It has several medicinally important properties (antidepressant, anti-inflammatory, proapoptotic, antibacterial and antiangiogenic). To enable its medicinal use, it is necessary to investigate its potential genotoxic effect on human cell lines. We also observed an anticlastogenic effect of hyperforin towards the indirect mutagen benzo(a)pyrene. Benzo(a)pyrene is a widespread polycyclic aromatic hydrocarbon. We performed experiments on human tumor cell line HepG2, using the in vitro mammalian chromosome aberration test. We investigated two cytogenic parameters: the number of aberrant metaphases and the total number of chromosome aberrations. We found out that hyperforin was not genotoxic on human cell line HepG2. The second part of our results implies that hyperforin had an anticlastogenic effect against the indirect mutagen benzo(a)pyrene in our experimental conditions. In future we will continue our research by using another range of hyperforin concentrations, other cell lines and other chemical mutagens.
- MeSH
- antidepresiva terapeutické užití toxicita MeSH
- antiflogistika terapeutické užití toxicita MeSH
- antimutagenní látky terapeutické užití toxicita MeSH
- benzopyreny * chemie MeSH
- biomedicínský výzkum MeSH
- buněčné linie cytologie účinky léků MeSH
- buňky Hep G2 cytologie účinky léků MeSH
- chromozomální aberace * chemicky indukované účinky léků MeSH
- lidé MeSH
- statistika jako téma MeSH
- třezalka * chemie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
- MeSH
- biotransformace MeSH
- Chlamydomonas reinhardtii metabolismus MeSH
- fluoreny metabolismus MeSH
- mutageny toxicita MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- srovnávací studie MeSH
