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Autor
Aguiar, Eliana 1 Algarra, Lorenzo 1 Amigo, Maria Luz 1 Bergua, Juan Miguel 1 Brioso, Joana 1 Caballero, Mar 1 Celebrin, Lucía 1 Cichocka, Edyta 1 Díez, María Elena Amutio 1 García-Álvarez, Flor 1 Garrido, Ana 1 González-Campos, Jose 1 Knopinska-Posluszny, Wanda 1 Labrador, Jorge 1 Martínez-Cuadrón, David 1 Mayer, Jiri 1 Montesinos, Pau 1 Perez-Encinas, Manuel Mateo 1 Piątkowska-Jakubas, Beata 1 Pluta, Agnieszka 1
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Pracoviště
Centro Hospitalar Săo Joăo Porto Port... 1 Collegium Medicum Jagiellonian Univer... 1 Department of Hematology Blood Neopla... 1 Department of Hematology Research Uni... 1 Department of Hematology and Transpla... 1 Department of Mathematics and Compute... 1 Faculty of Pure and Applied Mathemati... 1 Hospital 12 de Octubre Madrid Spain 1 Hospital Central de Asturias Oviedo S... 1 Hospital Clínico San Carlos Madrid Spain 1 Hospital Dr Peset Valencia Spain 1 Hospital General de Albacete Albacete... 1 Hospital Insular de Las Palmas Las Pa... 1 Hospital Maciel Montevideo Uruguay 1 Hospital Morales Meseguer Murcia Spain 1 Hospital Puerta de Hierro Madrid Spain 1 Hospital San Pedro de Alcántara Cacer... 1 Hospital Sant Pau Barcelona Spain 1 Hospital Tornú Buenos Aires Argentina 1 Hospital U Germans Trias i Pujol ICO ... 1
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Aguiar, Eliana 1 Algarra, Lorenzo 1 Amigo, Maria Luz 1 Bergua, Juan Miguel 1 Brioso, Joana 1 Caballero, Mar 1 Celebrin, Lucía 1 Cichocka, Edyta 1 Díez, María Elena Amutio 1 García-Álvarez, Flor 1 Garrido, Ana 1 González-Campos, Jose 1 Knopinska-Posluszny, Wanda 1 Labrador, Jorge 1 Martínez-Cuadrón, David 1 Mayer, Jiri 1 Montesinos, Pau 1 Perez-Encinas, Manuel Mateo 1 Piątkowska-Jakubas, Beata 1 Pluta, Agnieszka 1
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Pracoviště
Centro Hospitalar Săo Joăo Porto Port... 1 Collegium Medicum Jagiellonian Univer... 1 Department of Hematology Blood Neopla... 1 Department of Hematology Research Uni... 1 Department of Hematology and Transpla... 1 Department of Mathematics and Compute... 1 Faculty of Pure and Applied Mathemati... 1 Hospital 12 de Octubre Madrid Spain 1 Hospital Central de Asturias Oviedo S... 1 Hospital Clínico San Carlos Madrid Spain 1 Hospital Dr Peset Valencia Spain 1 Hospital General de Albacete Albacete... 1 Hospital Insular de Las Palmas Las Pa... 1 Hospital Maciel Montevideo Uruguay 1 Hospital Morales Meseguer Murcia Spain 1 Hospital Puerta de Hierro Madrid Spain 1 Hospital San Pedro de Alcántara Cacer... 1 Hospital Sant Pau Barcelona Spain 1 Hospital Tornú Buenos Aires Argentina 1 Hospital U Germans Trias i Pujol ICO ... 1
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The most important challenges in acute promyelocytic leukemia (APL) is preventing early death and reducing long-term events, such as second neoplasms (s-NPLs). We performed a retrospective analysis of 2670 unselected APL patients, treated with PETHEMA "chemotherapy based" and "chemotherapy free" protocols. Only de novo APL patients who achieved complete remission (CR) and completed the three consolidation cycles were enrolled into the analysis. Out of 2670 APL patients, there were 118 (4.4%) who developed s-NPLs with the median latency period (between first CR and diagnosis of s-NPL) of 48.0 months (range 2.8-231.1): 43.3 (range: 2.8-113.9) for s-MDS/AML and 61.7 (range: 7.1-231.1) for solid tumour. The 5-year CI of all s-NPLs was of 4.43% and 10 years of 7.92%. Among s-NPLs, there were 58 cases of s-MDS/AML, 3 cases of other hematological neoplasms, 57 solid tumours and 1 non-identified neoplasm. The most frequent solid tumour was colorectal, lung and breast cancer. Overall, the 2-year OS from diagnosis of s-NPLs was 40.6%, with a median OS of 11.1 months. Multivariate analysis identified age of 35 years (hazard ratio = 0.2584; p < 0.0001) as an independent prognostic factor for s-NPLs. There were no significant differences in CI of s-NPLs at 5 years between chemotherapy-based vs chemotherapy-free regimens (hazard ratio = 1.09; p = 0.932). Larger series with longer follow-up are required to confirm the potential impact of ATO+ATRA regimens to reduce the incidence of s-NPLs after front-line therapy for APL.
- MeSH
- akutní promyelocytární leukemie diagnóza farmakoterapie epidemiologie MeSH
- dospělí MeSH
- incidence MeSH
- lidé MeSH
- patologická kompletní odpověď MeSH
- protokoly antitumorózní kombinované chemoterapie terapeutické užití MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- sekundární malignity farmakoterapie MeSH
- tretinoin MeSH
- výsledek terapie MeSH
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- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
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