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Autor
Bednarik, Josef 1 Boerger, Timothy F 1 Curt, Armin 1 Davies, Benjamin M 1 Dhillon, Rana S 1 Fehlings, Michael G 1 Freund, Patrick 1 Gharooni, Aref-Ali 1 Guest, James D 1 Harrop, James S 1 Koljonen, Paul Aarne 1 Kotter, Mark R N 1 Kurpad, Shekar N 1 Kwon, Brian K 1 Martin, Allan R 1 Mowforth, Oliver 1 Newcombe, Virginia Fj 1 Nouri, Aria 1 Rahimi-Movaghar, Vafa 1 Rodrigues-Pinto, Ricardo 1
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Pracoviště
Department of Neurological Surgery 65... 1 Department of Neurology University Ho... 1 Department of Neurosurgery 2152Univer... 1 Department of Neurosurgery 5506Medica... 1 Department of Neurosurgery 60078St Vi... 1 Department of Neurosurgery 8789Univer... 1 Department of Neurosurgery Sina Traum... 1 Department of Neurosurgery and the Mi... 1 Department of Orthopaedics and Trauma... 1 Department of Pathology Brain Researc... 1 Division of Anaesthesia Department of... 1 Division of Neurosurgery Department o... 1 Division of Neurosurgery Geneva Unive... 1 Instituto de Ciências Biomédicas Abel... 1 New York University Langone Health Gr... 1 Spinal Unit Department of Orthopaedic... 1 University Spine Center 31031Balgrist... 1 Vancouver Spine Surgery Institute Dep... 1
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Autor
Bednarik, Josef 1 Boerger, Timothy F 1 Curt, Armin 1 Davies, Benjamin M 1 Dhillon, Rana S 1 Fehlings, Michael G 1 Freund, Patrick 1 Gharooni, Aref-Ali 1 Guest, James D 1 Harrop, James S 1 Koljonen, Paul Aarne 1 Kotter, Mark R N 1 Kurpad, Shekar N 1 Kwon, Brian K 1 Martin, Allan R 1 Mowforth, Oliver 1 Newcombe, Virginia Fj 1 Nouri, Aria 1 Rahimi-Movaghar, Vafa 1 Rodrigues-Pinto, Ricardo 1
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Pracoviště
Department of Neurological Surgery 65... 1 Department of Neurology University Ho... 1 Department of Neurosurgery 2152Univer... 1 Department of Neurosurgery 5506Medica... 1 Department of Neurosurgery 60078St Vi... 1 Department of Neurosurgery 8789Univer... 1 Department of Neurosurgery Sina Traum... 1 Department of Neurosurgery and the Mi... 1 Department of Orthopaedics and Trauma... 1 Department of Pathology Brain Researc... 1 Division of Anaesthesia Department of... 1 Division of Neurosurgery Department o... 1 Division of Neurosurgery Geneva Unive... 1 Instituto de Ciências Biomédicas Abel... 1 New York University Langone Health Gr... 1 Spinal Unit Department of Orthopaedic... 1 University Spine Center 31031Balgrist... 1 Vancouver Spine Surgery Institute Dep... 1
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Free Medical Journals od 2011
PubMed Central od 2011
Europe PubMed Central od 2011
ProQuest Central od 2018-02-01
Open Access Digital Library od 2011-01-01
Open Access Digital Library od 2015-01-01
Health & Medicine (ProQuest) od 2018-02-01
ROAD: Directory of Open Access Scholarly Resources od 2011
PubMed
35174728
DOI
10.1177/21925682211057546
Knihovny.cz E-zdroje
STUDY DESIGN: Literature Review (Narrative). OBJECTIVE: To propose a new framework, to support the investigation and understanding of the pathobiology of DCM, AO Spine RECODE-DCM research priority number 5. METHODS: Degenerative cervical myelopathy is a common and disabling spinal cord disorder. In this perspective, we review key knowledge gaps between the clinical phenotype and our biological models. We then propose a reappraisal of the key driving forces behind DCM and an individual's susceptibility, including the proposal of a new framework. RESULTS: Present pathobiological and mechanistic knowledge does not adequately explain the disease phenotype; why only a subset of patients with visualized cord compression show clinical myelopathy, and the amount of cord compression only weakly correlates with disability. We propose that DCM is better represented as a function of several interacting mechanical forces, such as shear, tension and compression, alongside an individual's vulnerability to spinal cord injury, influenced by factors such as age, genetics, their cardiovascular, gastrointestinal and nervous system status, and time. CONCLUSION: Understanding the disease pathobiology is a fundamental research priority. We believe a framework of mechanical stress, vulnerability, and time may better represent the disease as a whole. Whilst this remains theoretical, we hope that at the very least it will inspire new avenues of research that better encapsulate the full spectrum of disease.
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