According to the modern imaginations chronic lung disease (CLD) in children is the significant risk factor of the development of bone formation disorders. 194 children at the age 10-16 years old with chronic pneumonia and chronic bronchitis were included to the investigation. The study examines the features of structural and functional condition of the bone tissue with taking into account the degree of duration severity of chronic lung diseases in children. It suggests that osteopenic syndrome in children with CLD is a constant companion of the duration of pathological process. The index of the bone strength has the significant relationship with the severity of the disease. The use of the modern noninvasive technologies can allow studying with the high accuracy the condition of the bone tissue in patients with CLD.
- MeSH
- chronická bronchitida * komplikace patofyziologie MeSH
- chronická nemoc MeSH
- denzitometrie * metody MeSH
- dítě MeSH
- kostní denzita MeSH
- lidé MeSH
- metabolické nemoci kostí * ultrasonografie MeSH
- mladiství MeSH
- osteoporóza * etiologie MeSH
- pediatrie MeSH
- pneumonie * komplikace patofyziologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
The study explores features of the immune status and justifies the role of the autonomic nervous system in the pathogenesis of sepsis in infants. We observed 172 children in early age; the study group included 135 children with sepsis (septicemic and septicopyemic types). Compared group comprised 37 patients with local types of infection (uncomplicated pneumonias, pyelonephritis, pseudofurunculosis, and others); and control group included 20 healthy children. Significant violations of adaptive-compensatory features with deep disturbances in the regulatory system were revealed in septic patients. Changes in the indexes of cardiointervalography such as decreasing of the mode (MO), increasing of the mode amplitude (AMO) and significant increasing of the tension index (TI) testified on increasing of sympathetic-adrenergic effects.
By means of the histological methods, scanning and transmission electronic microscopy the cerebral cortex of the brain (field 6), the walls of III and IV ventricles of the brain of dead people, who had died of acute anemia on the background of alcohol intoxication and drug intoxication, have been studied. Examination has found thinning of the basal membrane of capillaries, development of fissures in the places of contact of neighboring endothelial cells, also between basal membrane and endothelial cells, and swelling of pericytes. In the wall of brain ventricles, a marked polymorphism of the ependymal cells and disturbance of the continuity of the layer are noted. Accumulation of blood cells, thickening of detritus, crystal structures are seen on ependymal surface. Reported symptoms reflect the disturbance of permeability of hematoencephalic and liquor-encephalic barriers of the brain with a combination of traumatic blood loss with alcohol and drug intoxication.
- MeSH
- anemie * etiologie komplikace MeSH
- dospělí MeSH
- hematoencefalická bariéra fyziologie patologie MeSH
- krevní buňky patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mozek * krevní zásobení MeSH
- mozkomíšní mok MeSH
- pití alkoholu škodlivé účinky MeSH
- pitva MeSH
- příčina smrti MeSH
- zakázané drogy škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
We have studied features of physical development, calcium-phosphorus metabolism and mineral density of the bones in children with chronic lung diseases. Comparison of received results with the standards of physical development in children and adolescents has shown the most significant differences in ages of 10, 11 and 15 years old who had the stature level lower than average. The data obtained suggest that children with this pathology undergoes substantial adverse changes in the main somatomertric indicators and bone mineral density, the degree of which depends on the nature of the primary lesion in the bronchopulmonary system, and duration and severity of disease.
- MeSH
- chronická nemoc * MeSH
- dítě MeSH
- kostní denzita fyziologie MeSH
- lidé MeSH
- mladiství MeSH
- plicní nemoci * komplikace patofyziologie MeSH
- tělesné váhy a míry MeSH
- vývoj dítěte * MeSH
- vývoj kostí * fyziologie MeSH
- výzkumný projekt MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
Based on general histological and histochemical methods of investigation we have studied the comparative morphology of immune structures of jejunum in young rabbits in the different periods of early postnatal ontogenesis. The study has determined presence of morphological and morphometric differences between them, although the general principles of their structure has been identical. The localization density of intra-tissue lymphocytes has demonstrated intensive increase until 20 days of postnatal ontogenesis.
- Klíčová slova
- postnatální vývoj,
- MeSH
- jejunum * anatomie a histologie imunologie růst a vývoj MeSH
- králíci MeSH
- lymfocyty fyziologie MeSH
- vývojová biologie * MeSH
- výzkumný projekt MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- zvířata MeSH
By the results of DNA-diagnostic of gene Cx26 we have determined three types of patients. 39% of patients (146/374) belongs to the group of homozygote patients according to mutation of 35delG, genotype D/D. 14% of patients (57/374) belong to the group of heterozygote patients according to mutation of 35delG, genotype D/N. There were determined 23 cases with biallel inheritance of the mutation in gene Cx26 and 1 case of digenic inheritance mutation of 35delG in gene Cx26 and in a big deletion of gene Cx30.
- MeSH
- dítě MeSH
- genetické nemoci vrozené MeSH
- genetické testování MeSH
- genotyp * MeSH
- hluchota epidemiologie genetika vrozené MeSH
- konexiny * genetika MeSH
- lidé MeSH
- mutace MeSH
- mutační analýza DNA MeSH
- nedoslýchavost * epidemiologie genetika vrozené MeSH
- percepční nedoslýchavost epidemiologie genetika vrozené MeSH
- pokrevní příbuzenství MeSH
- prevalence MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Geografické názvy
- Uzbekistán MeSH
The paper studies clinical signs of hearing disorders caused by mutation in gene Cx26 in order to determine approaches to treatment and rehabilitation. The problem of primary prevention of such pathology as NSHL among children of Uzbek population is important thing in our region because of the high level of birth rate where we can see the marriages between two relatives who have blood relationship with each other (inbreeding). Factor of inbreeding comes out as additional precondition to investigate influence of the different genetic factors to NSHL in children. Determining mutation in gene Cx26 should lead to recommendation on testing this gene in all family members. In each specific case, during the obligatory medical and genetic consultation, we need to discuss on prevention of repeated cases in this family and in the following generations.
