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Autor
Balintova, Sona 1 Boukalova, Stepana 1 Cecchini, Gary 1 Cunatova, Kristyna 1 Dvorakova, Sarka 1 Ghayee, Hans K 1 Hadrava Vanova, Katerina 1 Iverson, T M 1 Kraus, Michal 1 Maklashina, Elena 1 Mracek, Tomas 1 Nahacka, Zuzana 1 Neuzil, Jiri 1 Pacak, Karel 1 Rohlena, Jakub 1 Sharma, Pankaj 1 Voehler, Markus 1 Zobalova, Renata 1
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Pracoviště
1st Faculty of Medicine Charles Unive... 1 Center for Structural Biology Vanderb... 1 Department of Biochemistry Vanderbilt... 1 Department of Biochemistry and Biophy... 1 Department of Chemistry Vanderbilt Un... 1 Department of Medicine Division of En... 1 Department of Pharmacology Vanderbilt... 1 Eunice Kennedy Shriver National Insti... 1 Faculty of Science Charles University... 1 Institute of Biotechnology Czech Acad... 1 Institute of Physiology Czech Academy... 1 Molecular Biology Division San Franci... 1 School of Pharmacy and Medical Scienc... 1 Vanderbilt Institute of Chemical Biol... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
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- Vlastník
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Autor
Balintova, Sona 1 Boukalova, Stepana 1 Cecchini, Gary 1 Cunatova, Kristyna 1 Dvorakova, Sarka 1 Ghayee, Hans K 1 Hadrava Vanova, Katerina 1 Iverson, T M 1 Kraus, Michal 1 Maklashina, Elena 1 Mracek, Tomas 1 Nahacka, Zuzana 1 Neuzil, Jiri 1 Pacak, Karel 1 Rohlena, Jakub 1 Sharma, Pankaj 1 Voehler, Markus 1 Zobalova, Renata 1
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Pracoviště
1st Faculty of Medicine Charles Unive... 1 Center for Structural Biology Vanderb... 1 Department of Biochemistry Vanderbilt... 1 Department of Biochemistry and Biophy... 1 Department of Chemistry Vanderbilt Un... 1 Department of Medicine Division of En... 1 Department of Pharmacology Vanderbilt... 1 Eunice Kennedy Shriver National Insti... 1 Faculty of Science Charles University... 1 Institute of Biotechnology Czech Acad... 1 Institute of Physiology Czech Academy... 1 Molecular Biology Division San Franci... 1 School of Pharmacy and Medical Scienc... 1 Vanderbilt Institute of Chemical Biol... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
Free Medical Journals od 2010
Nature Open Access od 2010-12-01
PubMed Central od 2012
Europe PubMed Central od 2012
ProQuest Central od 2010-01-01
Open Access Digital Library od 2015-01-01
Open Access Digital Library od 2015-01-01
Medline Complete (EBSCOhost) od 2012-11-01
Health & Medicine (ProQuest) od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources od 2010
PubMed
38212624
DOI
10.1038/s41467-023-44563-7
Knihovny.cz E-zdroje
Complex II (CII) activity controls phenomena that require crosstalk between metabolism and signaling, including neurodegeneration, cancer metabolism, immune activation, and ischemia-reperfusion injury. CII activity can be regulated at the level of assembly, a process that leverages metastable assembly intermediates. The nature of these intermediates and how CII subunits transfer between metastable complexes remains unclear. In this work, we identify metastable species containing the SDHA subunit and its assembly factors, and we assign a preferred temporal sequence of appearance of these species during CII assembly. Structures of two species show that the assembly factors undergo disordered-to-ordered transitions without the appearance of significant secondary structure. The findings identify that intrinsically disordered regions are critical in regulating CII assembly, an observation that has implications for the control of assembly in other biomolecular complexes.
- MeSH
- katalytická doména * MeSH
- sekundární struktura proteinů MeSH
- Publikační typ
- časopisecké články MeSH
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Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.