After the approval of the first therapeutic monoclonal antibodies and their successful introduction into therapy, agreat future was expected for this class of drugs. This assumption has been fulfilled to a limited extent only, es-pecially in the treatment of oncological problems, some autoimmune diseases and in the treatment of some rare diseases. On the other hand, a considerable progress has been made in the fields of oncology and autoimmune dis-eases by discovering protein kinases, and these small mol-eculedrugsrepresentalternativesinthetreatmentofarange of such diseases. In this article, we have tried to shed light mainly on the role of small molecules in thera-py, including problems connected with the development of this class of drugs. For many of them, their physico-chemical properties prevent using traditional formulation techniques and modern technologies must be applied. This paper summarizes the most commonly used approaches for increasing bioavailability, including both the prodrug ap-proach and the use of various solid forms of the active ingredient in specific formulations available on the market. The article also provides examples of practical use of amorphous solid dispersions and modern trends, including the development of various types of lipid formulations.
- Klíčová slova
- malé molekuly,
- MeSH
- biologická terapie metody MeSH
- biologické přípravky farmakologie terapeutické užití MeSH
- biosimilární léčivé přípravky terapeutické užití MeSH
- léčivé přípravky * MeSH
- lidé MeSH
- monoklonální protilátky farmakologie terapeutické užití MeSH
- prekurzory léčiv farmakologie terapeutické užití MeSH
- tyrosinkinasy antagonisté a inhibitory MeSH
- vyvíjení léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- MeSH
- farmakokinetika MeSH
- kongresy jako téma MeSH
- lékové formy MeSH
- lékové interakce MeSH
- Publikační typ
- práce podpořená grantem MeSH
Hot-stage microscopy (HSM) affords combined light microscopy and thermal analysis, enabling the study of materials as a function of temperature and time. This combination involves visual examination and gives valuable information on the compound regarding its melting point, phase transformation, new phase formation, solid-state interactions, particle and solid dispersions analysis during heating. HSM gives a unique opportunity to visually follow thermal changes. Model cases of HSM application show its current usage in pharmaceutical industry thus supporting and inspiring its research.
- Klíčová slova
- mikroskopie s vyhřívaným stolkem, hot-stage mikroskopie,
- MeSH
- chemické jevy MeSH
- farmaceutický průmysl trendy MeSH
- léčivé přípravky chemie MeSH
- mikroskopie * přístrojové vybavení využití MeSH
- teplota MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Publikační typ
- abstrakt z konference MeSH
