This study investigates the toxicity of WGP 3-6, a yeast-derived beta-glucan ingredient, during single-dose acute and sub-chronic toxicity studies in rats. For the acute study, Fisher-344 rats were administered WGP 3-6 via gavage at a dose of 2000 mg/kg body weight, and any evidence of toxicity was monitored over a 14-day period. WGP 3-6 was well tolerated, indicating that the LD(50) value is greater than 2000 mg/kg body weight. For the sub-chronic study, Fisher-344 rats (10/sex/group) were randomly allocated to receive daily gavage treatment with WGP 3-6 at doses of 0, 2, 33.3, or 100 mg/kg body weight. Control and high-dose satellite recovery groups of each sex also were included. Full toxicological monitoring and endpoint investigations were performed throughout and upon completion of the study. No negative effects on animal weights or food consumption attributable to WGP 3-6 were evident at any dose. In addition, no mortality, clinical pathology, functional/behavioral, microscopic, or gross observations indicating toxicity were observed. Sporadic changes in some biochemical and hematological parameters were observed; however, since the effects were within the physiological ranges in historical controls, were not dose-responsive, or were not observed in both sexes, they were determined to be of no toxicological significance. In conclusion, no adverse or toxic effects were observed after subchronic oral administration of 2, 33.3, or 100mg/kg body weight/day of WGP 3-6 in Fisher-344 rats, and therefore, a no observed adverse effect level (NOAEL) of 100 mg/kg body weight/day, the highest dose tested, was determined.
- MeSH
- analýza rozptylu MeSH
- beta-glukany toxicita MeSH
- biochemická analýza krve MeSH
- dávka bez pozorovaného nepříznivého účinku MeSH
- gastrointestinální intubace MeSH
- hematologické testy MeSH
- krysa rodu rattus MeSH
- LD50 MeSH
- náhodné rozdělení MeSH
- potkani inbrední F344 MeSH
- Saccharomyces cerevisiae chemie MeSH
- tělesná hmotnost účinky léků MeSH
- testy akutní toxicity MeSH
- testy chronické toxicity MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- MeSH
- glukany chemická syntéza imunologie MeSH
- makrofágy imunologie sekrece MeSH
- monocyty imunologie sekrece MeSH
- myši MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Klíčová slova
- ALLTRACEL MDOC,
- MeSH
- celulosa oxidovaná aplikace a dávkování farmakologie MeSH
- injekce intraperitoneální využití MeSH
- krev účinky léků MeSH
- krysa rodu rattus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
