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Autor
Biering-Sørensen, Tor 4 Abbasi, Siddique A 3 Bonderman, Diana 3 Böhm, Michael 3 Diaz, Rafael 3 Fang, James C 3 Felker, G Michael 3 Lanfear, David E 3 Lund, Mayanna 3 Malik, Fady I 3 McMurray, John J V 3 Metra, Marco 3 Momomura, Shin-Ichi 3 O'Meara, Eileen 3 Ponikowski, Piotr 3 Solomon, Scott D 3 Spinar, Jindrich 3 Teerlink, John R 3 Adams, Kirkwood F 2 Anand, Inder 2
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Pracoviště
Saitama Citizens Medical Center Saita... 3 Wroclaw Medical University Wroclaw Po... 3 AZ Sint Lucas Ghent Belgium 2 Department of Cardiology Herlev and G... 2 Dokuz Eylul University Izmir Turkey 2 Estudios Clinicos Latino America Rosa... 2 Institute of Cardiology Kyiv Ukraine 2 Medical University of Vienna Vienna A... 2 Saarland University Universitätsklini... 2 St John of God Hospital Budapest Hungary 2 Vilnius University Vilnius Lithuania 2 Amgen Inc Thousand Oaks CA USA 1 Amgen Inc Thousand Oaks California USA 1 Bern University Hospital University o... 1 British Heart Foundation Cardiovascul... 1 British Heart Foundation Cardiovascul... 1 Cardiology ASST Spedali Civili 1 Cardiology ASST Spedali Civili Depart... 1 Cardiology ASST Spedali Civili Depart... 1 Cardiology Department Middlemore Hosp... 1
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Autor
Biering-Sørensen, Tor 4 Abbasi, Siddique A 3 Bonderman, Diana 3 Böhm, Michael 3 Diaz, Rafael 3 Fang, James C 3 Felker, G Michael 3 Lanfear, David E 3 Lund, Mayanna 3 Malik, Fady I 3 McMurray, John J V 3 Metra, Marco 3 Momomura, Shin-Ichi 3 O'Meara, Eileen 3 Ponikowski, Piotr 3 Solomon, Scott D 3 Spinar, Jindrich 3 Teerlink, John R 3 Adams, Kirkwood F 2 Anand, Inder 2
- Organizace
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Pracoviště
Saitama Citizens Medical Center Saita... 3 Wroclaw Medical University Wroclaw Po... 3 AZ Sint Lucas Ghent Belgium 2 Department of Cardiology Herlev and G... 2 Dokuz Eylul University Izmir Turkey 2 Estudios Clinicos Latino America Rosa... 2 Institute of Cardiology Kyiv Ukraine 2 Medical University of Vienna Vienna A... 2 Saarland University Universitätsklini... 2 St John of God Hospital Budapest Hungary 2 Vilnius University Vilnius Lithuania 2 Amgen Inc Thousand Oaks CA USA 1 Amgen Inc Thousand Oaks California USA 1 Bern University Hospital University o... 1 British Heart Foundation Cardiovascul... 1 British Heart Foundation Cardiovascul... 1 Cardiology ASST Spedali Civili 1 Cardiology ASST Spedali Civili Depart... 1 Cardiology ASST Spedali Civili Depart... 1 Cardiology Department Middlemore Hosp... 1
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Open Access Digital Library od 1996-01-01
PubMed
36017572
DOI
10.1093/eurheartj/ehac262
Knihovny.cz E-zdroje
- MeSH
- lidé MeSH
- náhlá srdeční smrt * prevence a kontrola MeSH
- srdeční arytmie * komplikace terapie MeSH
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Teerlink, John R
Autor Teerlink, John R From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California Estudios Clínicos Latino América, Rosario, Argentina (R.D.) the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.) the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.) the University of Minnesota, Minneapolis (I.A.) Instituto Nacional de Cardiología, Mexico City (A.A.-M.) the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.) Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.) Medical University of Vienna, Vienna (D.B.) Pontificia Universidad Católica de Chile, Santiago (R.C.) Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.) the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.) Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.) University of Utah, Salt Lake City (J.C.F.) National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.) Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.) Commenius University, Bratislava, Slovakia (E.G.) the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.) Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.) the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.) Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.) St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.) University Clinic of Lomonosov, Moscow State University, Moscow (V.M.) Saitama Citizens Medical Center, Saitama, Japan (S.M.) Institute of Cardiology, Kyiv, Ukraine (A.P.) Wroclaw Medical University, Wroclaw, Poland (P.P.) Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.) Vilnius University, Vilnius, Lithuania (P.S.) the University of Cape Town, Cape Town, South Africa (K.S.) the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.) the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.) St. John of God Hospital, Budapest, Hungary (J.T.) AZ Sint-Lucas, Ghent, Belgium (H.V.) the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.) the University of Groningen, Groningen, the Netherlands (A.A.V.) Dokuz Eylul University, Izmir, Turkey (M.B.Y.) and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France
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Diaz, Rafael
Autor Diaz, Rafael From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California Estudios Clínicos Latino América, Rosario, Argentina (R.D.) the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.) the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.) the University of Minnesota, Minneapolis (I.A.) Instituto Nacional de Cardiología, Mexico City (A.A.-M.) the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.) Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.) Medical University of Vienna, Vienna (D.B.) Pontificia Universidad Católica de Chile, Santiago (R.C.) Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.) the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.) Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.) University of Utah, Salt Lake City (J.C.F.) National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.) Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.) Commenius University, Bratislava, Slovakia (E.G.) the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.) Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.) the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.) Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.) St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.) University Clinic of Lomonosov, Moscow State University, Moscow (V.M.) Saitama Citizens Medical Center, Saitama, Japan (S.M.) Institute of Cardiology, Kyiv, Ukraine (A.P.) Wroclaw Medical University, Wroclaw, Poland (P.P.) Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.) Vilnius University, Vilnius, Lithuania (P.S.) the University of Cape Town, Cape Town, South Africa (K.S.) the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.) the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.) St. John of God Hospital, Budapest, Hungary (J.T.) AZ Sint-Lucas, Ghent, Belgium (H.V.) the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.) the University of Groningen, Groningen, the Netherlands (A.A.V.) Dokuz Eylul University, Izmir, Turkey (M.B.Y.) and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France
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Felker, G Michael
Autor Felker, G Michael From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California Estudios Clínicos Latino América, Rosario, Argentina (R.D.) the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.) the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.) the University of Minnesota, Minneapolis (I.A.) Instituto Nacional de Cardiología, Mexico City (A.A.-M.) the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.) Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.) Medical University of Vienna, Vienna (D.B.) Pontificia Universidad Católica de Chile, Santiago (R.C.) Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.) the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.) Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.) University of Utah, Salt Lake City (J.C.F.) National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.) Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.) Commenius University, Bratislava, Slovakia (E.G.) the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.) Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.) the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.) Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.) St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.) University Clinic of Lomonosov, Moscow State University, Moscow (V.M.) Saitama Citizens Medical Center, Saitama, Japan (S.M.) Institute of Cardiology, Kyiv, Ukraine (A.P.) Wroclaw Medical University, Wroclaw, Poland (P.P.) Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.) Vilnius University, Vilnius, Lithuania (P.S.) the University of Cape Town, Cape Town, South Africa (K.S.) the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.) the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.) St. John of God Hospital, Budapest, Hungary (J.T.) AZ Sint-Lucas, Ghent, Belgium (H.V.) the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.) the University of Groningen, Groningen, the Netherlands (A.A.V.) Dokuz Eylul University, Izmir, Turkey (M.B.Y.) and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France
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McMurray, John J V
Autor McMurray, John J V From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California Estudios Clínicos Latino América, Rosario, Argentina (R.D.) the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.) the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.) the University of Minnesota, Minneapolis (I.A.) Instituto Nacional de Cardiología, Mexico City (A.A.-M.) the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.) Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.) Medical University of Vienna, Vienna (D.B.) Pontificia Universidad Católica de Chile, Santiago (R.C.) Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.) the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.) Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.) University of Utah, Salt Lake City (J.C.F.) National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.) Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.) Commenius University, Bratislava, Slovakia (E.G.) the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.) Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.) the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.) Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.) St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.) University Clinic of Lomonosov, Moscow State University, Moscow (V.M.) Saitama Citizens Medical Center, Saitama, Japan (S.M.) Institute of Cardiology, Kyiv, Ukraine (A.P.) Wroclaw Medical University, Wroclaw, Poland (P.P.) Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.) Vilnius University, Vilnius, Lithuania (P.S.) the University of Cape Town, Cape Town, South Africa (K.S.) the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.) the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.) St. John of God Hospital, Budapest, Hungary (J.T.) AZ Sint-Lucas, Ghent, Belgium (H.V.) the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.) the University of Groningen, Groningen, the Netherlands (A.A.V.) Dokuz Eylul University, Izmir, Turkey (M.B.Y.) and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France
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Metra, Marco
Autor Metra, Marco From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California Estudios Clínicos Latino América, Rosario, Argentina (R.D.) the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.) the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.) the University of Minnesota, Minneapolis (I.A.) Instituto Nacional de Cardiología, Mexico City (A.A.-M.) the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.) Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.) Medical University of Vienna, Vienna (D.B.) Pontificia Universidad Católica de Chile, Santiago (R.C.) Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.) the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.) Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.) University of Utah, Salt Lake City (J.C.F.) National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.) Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.) Commenius University, Bratislava, Slovakia (E.G.) the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.) Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.) the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.) Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.) St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.) University Clinic of Lomonosov, Moscow State University, Moscow (V.M.) Saitama Citizens Medical Center, Saitama, Japan (S.M.) Institute of Cardiology, Kyiv, Ukraine (A.P.) Wroclaw Medical University, Wroclaw, Poland (P.P.) Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.) Vilnius University, Vilnius, Lithuania (P.S.) the University of Cape Town, Cape Town, South Africa (K.S.) the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.) the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.) St. John of God Hospital, Budapest, Hungary (J.T.) AZ Sint-Lucas, Ghent, Belgium (H.V.) the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.) the University of Groningen, Groningen, the Netherlands (A.A.V.) Dokuz Eylul University, Izmir, Turkey (M.B.Y.) and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France
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Solomon, Scott D
Autor Solomon, Scott D From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California Estudios Clínicos Latino América, Rosario, Argentina (R.D.) the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.) the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.) the University of Minnesota, Minneapolis (I.A.) Instituto Nacional de Cardiología, Mexico City (A.A.-M.) the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.) Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.) Medical University of Vienna, Vienna (D.B.) Pontificia Universidad Católica de Chile, Santiago (R.C.) Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.) the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.) Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.) University of Utah, Salt Lake City (J.C.F.) National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.) Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.) Commenius University, Bratislava, Slovakia (E.G.) the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.) Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.) the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.) Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.) St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.) University Clinic of Lomonosov, Moscow State University, Moscow (V.M.) Saitama Citizens Medical Center, Saitama, Japan (S.M.) Institute of Cardiology, Kyiv, Ukraine (A.P.) Wroclaw Medical University, Wroclaw, Poland (P.P.) Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.) Vilnius University, Vilnius, Lithuania (P.S.) the University of Cape Town, Cape Town, South Africa (K.S.) the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.) the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.) St. John of God Hospital, Budapest, Hungary (J.T.) AZ Sint-Lucas, Ghent, Belgium (H.V.) the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.) the University of Groningen, Groningen, the Netherlands (A.A.V.) Dokuz Eylul University, Izmir, Turkey (M.B.Y.) and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France
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Adams, Kirkwood F
Autor Adams, Kirkwood F From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California Estudios Clínicos Latino América, Rosario, Argentina (R.D.) the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.) the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.) the University of Minnesota, Minneapolis (I.A.) Instituto Nacional de Cardiología, Mexico City (A.A.-M.) the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.) Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.) Medical University of Vienna, Vienna (D.B.) Pontificia Universidad Católica de Chile, Santiago (R.C.) Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.) the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.) Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.) University of Utah, Salt Lake City (J.C.F.) National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.) Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.) Commenius University, Bratislava, Slovakia (E.G.) the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.) Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.) the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.) Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.) St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.) University Clinic of Lomonosov, Moscow State University, Moscow (V.M.) Saitama Citizens Medical Center, Saitama, Japan (S.M.) Institute of Cardiology, Kyiv, Ukraine (A.P.) Wroclaw Medical University, Wroclaw, Poland (P.P.) Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.) Vilnius University, Vilnius, Lithuania (P.S.) the University of Cape Town, Cape Town, South Africa (K.S.) the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.) the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.) St. John of God Hospital, Budapest, Hungary (J.T.) AZ Sint-Lucas, Ghent, Belgium (H.V.) the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.) the University of Groningen, Groningen, the Netherlands (A.A.V.) Dokuz Eylul University, Izmir, Turkey (M.B.Y.) and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France
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Anand, Inder
Autor Anand, Inder From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California Estudios Clínicos Latino América, Rosario, Argentina (R.D.) the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.) the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.) the University of Minnesota, Minneapolis (I.A.) Instituto Nacional de Cardiología, Mexico City (A.A.-M.) the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.) Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.) Medical University of Vienna, Vienna (D.B.) Pontificia Universidad Católica de Chile, Santiago (R.C.) Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.) the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.) Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.) University of Utah, Salt Lake City (J.C.F.) National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.) Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.) Commenius University, Bratislava, Slovakia (E.G.) the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.) Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.) the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.) Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.) St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.) University Clinic of Lomonosov, Moscow State University, Moscow (V.M.) Saitama Citizens Medical Center, Saitama, Japan (S.M.) Institute of Cardiology, Kyiv, Ukraine (A.P.) Wroclaw Medical University, Wroclaw, Poland (P.P.) Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.) Vilnius University, Vilnius, Lithuania (P.S.) the University of Cape Town, Cape Town, South Africa (K.S.) the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.) the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.) St. John of God Hospital, Budapest, Hungary (J.T.) AZ Sint-Lucas, Ghent, Belgium (H.V.) the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.) the University of Groningen, Groningen, the Netherlands (A.A.V.) Dokuz Eylul University, Izmir, Turkey (M.B.Y.) and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France
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Arias-Mendoza, Alexandra
Autor Arias-Mendoza, Alexandra From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California Estudios Clínicos Latino América, Rosario, Argentina (R.D.) the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.) the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.) the University of Minnesota, Minneapolis (I.A.) Instituto Nacional de Cardiología, Mexico City (A.A.-M.) the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.) Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.) Medical University of Vienna, Vienna (D.B.) Pontificia Universidad Católica de Chile, Santiago (R.C.) Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.) the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.) Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.) University of Utah, Salt Lake City (J.C.F.) National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.) Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.) Commenius University, Bratislava, Slovakia (E.G.) the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.) Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.) the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.) Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.) St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.) University Clinic of Lomonosov, Moscow State University, Moscow (V.M.) Saitama Citizens Medical Center, Saitama, Japan (S.M.) Institute of Cardiology, Kyiv, Ukraine (A.P.) Wroclaw Medical University, Wroclaw, Poland (P.P.) Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.) Vilnius University, Vilnius, Lithuania (P.S.) the University of Cape Town, Cape Town, South Africa (K.S.) the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.) the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.) St. John of God Hospital, Budapest, Hungary (J.T.) AZ Sint-Lucas, Ghent, Belgium (H.V.) the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.) the University of Groningen, Groningen, the Netherlands (A.A.V.) Dokuz Eylul University, Izmir, Turkey (M.B.Y.) and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France
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Biering-Sørensen, Tor
Autor Biering-Sørensen, Tor From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California Estudios Clínicos Latino América, Rosario, Argentina (R.D.) the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.) the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.) the University of Minnesota, Minneapolis (I.A.) Instituto Nacional de Cardiología, Mexico City (A.A.-M.) the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.) Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.) Medical University of Vienna, Vienna (D.B.) Pontificia Universidad Católica de Chile, Santiago (R.C.) Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.) the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.) Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.) University of Utah, Salt Lake City (J.C.F.) National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.) Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.) Commenius University, Bratislava, Slovakia (E.G.) the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.) Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.) the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.) Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.) St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.) University Clinic of Lomonosov, Moscow State University, Moscow (V.M.) Saitama Citizens Medical Center, Saitama, Japan (S.M.) Institute of Cardiology, Kyiv, Ukraine (A.P.) Wroclaw Medical University, Wroclaw, Poland (P.P.) Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.) Vilnius University, Vilnius, Lithuania (P.S.) the University of Cape Town, Cape Town, South Africa (K.S.) the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.) the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.) St. John of God Hospital, Budapest, Hungary (J.T.) AZ Sint-Lucas, Ghent, Belgium (H.V.) the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.) the University of Groningen, Groningen, the Netherlands (A.A.V.) Dokuz Eylul University, Izmir, Turkey (M.B.Y.) and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France
Nursing & Allied Health Database (ProQuest) od 1980-01-03 do Před 3 měsíci
Health & Medicine (ProQuest) od 1980-01-03 do Před 3 měsíci
Family Health Database (ProQuest) od 1980-01-03 do Před 3 měsíci
Psychology Database (ProQuest) od 1980-01-03 do Před 3 měsíci
Health Management Database (ProQuest) od 1980-01-03 do Před 3 měsíci
Public Health Database (ProQuest) od 1980-01-03 do Před 3 měsíci
PubMed
33185990
DOI
10.1056/nejmoa2025797
Knihovny.cz E-zdroje
BACKGROUND: The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS: We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS: During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS: Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016-002299-28.).
- MeSH
- kardiotonika škodlivé účinky farmakologie terapeutické užití MeSH
- kardiovaskulární nemoci mortalita MeSH
- kontrakce myokardu účinky léků MeSH
- lidé středního věku MeSH
- lidé MeSH
- močovina škodlivé účinky analogy a deriváty farmakologie terapeutické užití MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- srdeční myosiny účinky léků metabolismus MeSH
- systolické srdeční selhání farmakoterapie metabolismus patofyziologie MeSH
- tepový objem MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky, fáze III MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
Open Access Digital Library od 1998-01-01
Elsevier Open Archive Journals od 1983-01-01 do Před 1 rokem
PubMed
34015475
DOI
10.1016/j.jacc.2021.04.065
Knihovny.cz E-zdroje
BACKGROUND: In GALACTIC-HF (Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure) (n = 8,256), the cardiac myosin activator, omecamtiv mecarbil, significantly reduced the primary composite endpoint (PCE) of time-to-first heart failure event or cardiovascular death in patients with heart failure and reduced ejection fraction (EF) (≤35%). OBJECTIVES: The purpose of this study was to evaluate the influence of baseline EF on the therapeutic effect of omecamtiv mecarbil. METHODS: Outcomes in patients treated with omecamtiv mecarbil were compared with placebo according to EF. RESULTS: The risk of the PCE in the placebo group was nearly 1.8-fold greater in the lowest EF (≤22%) compared with the highest EF (≥33%) quartile. Amongst the pre-specified subgroups, EF was the strongest modifier of the treatment effect of omecamtiv mecarbil on the PCE (interaction as continuous variable, p = 0.004). Patients receiving omecamtiv mecarbil had a progressively greater relative and absolute treatment effect as baseline EF decreased, with a 17% relative risk reduction for the PCE in patients with baseline EF ≤22% (n = 2,246; hazard ratio: 0.83; 95% confidence interval: 0.73 to 0.95) compared with patients with EF ≥33% (n = 1,750; hazard ratio: 0.99; 95% confidence interval: 0.84 to 1.16; interaction as EF by quartiles, p = 0.013). The absolute reduction in the PCE increased with decreasing EF (EF ≤22%; absolute risk reduction, 7.4 events per 100 patient-years; number needed to treat for 3 years = 11.8), compared with no reduction in the highest EF quartile. CONCLUSIONS: In heart failure patients with reduced EF, omecamtiv mecarbil produced greater therapeutic benefit as baseline EF decreased. These findings are consistent with the drug's mechanism of selectively improving systolic function and presents an important opportunity to improve the outcomes in a group of patients at greatest risk. (Registrational Study With Omecamtiv Mecarbil/AMG 423 to Treat Chronic Heart Failure With Reduced Ejection Fraction [GALACTIC-HF]; NCT02929329).
- MeSH
- lidé středního věku MeSH
- lidé MeSH
- močovina analogy a deriváty terapeutické užití MeSH
- senioři MeSH
- srdeční selhání farmakoterapie MeSH
- tepový objem * MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky, fáze III MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
PubMed
32985088
DOI
10.1002/ejhf.2015
Knihovny.cz E-zdroje
AIMS: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is being tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC-HF) trial. Here we describe the baseline characteristics of participants in GALACTIC-HF and how these compare with other contemporary trials. METHODS AND RESULTS: Adults with established HFrEF, New York Heart Association (NYHA) functional class ≥II, ejection fraction ≤35%, elevated natriuretic peptides and either current hospitalization for heart failure or history of hospitalization/emergency department visit for heart failure within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic-guided dosing: 25, 37.5, or 50 mg bid). A total of 8256 patients [male (79%), non-white (22%), mean age 65 years] were enrolled with a mean ejection fraction 27%, ischaemic aetiology in 54%, NYHA class II 53% and III/IV 47%, and median N-terminal pro-B-type natriuretic peptide 1971 pg/mL. Heart failure therapies at baseline were among the most effectively employed in contemporary heart failure trials. GALACTIC-HF randomized patients representative of recent heart failure registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure <100 mmHg (n = 1127), estimated glomerular filtration rate <30 mL/min/1.73 m2 (n = 528), and treated with sacubitril/valsartan at baseline (n = 1594). CONCLUSIONS: GALACTIC-HF enrolled a well-treated, high-risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation.
- MeSH
- funkce levé komory srdeční účinky léků MeSH
- lidé středního věku MeSH
- lidé MeSH
- močovina analogy a deriváty terapeutické užití MeSH
- randomizované kontrolované studie jako téma MeSH
- senioři MeSH
- srdeční selhání * farmakoterapie patofyziologie MeSH
- tepový objem účinky léků MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
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