- MeSH
- Blood Pressure Monitoring, Ambulatory MeSH
- Cystatin C metabolism MeSH
- Diastole physiology MeSH
- Electrocardiography MeSH
- Essential Hypertension diagnostic imaging drug therapy physiopathology MeSH
- Glomerular Filtration Rate MeSH
- Blood Pressure physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Multivariate Analysis MeSH
- ROC Curve MeSH
- Kidney Function Tests * MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
OBJECTIVE: To evaluate whether plasma adrenomedullin is involved in the previously reported significant inverse correlation between left ventricular (LV) end-diastolic pressure (peak velocity of early transmitral flow/peak velocity of early diastolic mitral annular motion ratio [E/E' ]) and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus, mild-to-moderate renal function impairment and LV relaxation impairment (E'≤7.1 cm/s). METHODS: Plasma adrenomedullin concentration, E/E' and eGFR were assessed in 82 patients with type 2 diabetes. RESULTS: Plasma adrenomedullin concentration was positively correlated with eGFR in patients with or without LV relaxation impairment, and inversely correlated with E/E' in patients with LV relaxation impairment. Multivariate linear regression analysis supported a role for plasma adrenomedullin in the association between E/E' and eGFR. CONCLUSION: These results support the hypothesis that adrenomedullin modulates the interaction between the heart and kidneys in early subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus.
- MeSH
- Adrenomedullin blood MeSH
- Diabetes Mellitus, Type 2 blood complications physiopathology MeSH
- Ventricular Dysfunction, Left blood etiology physiopathology MeSH
- Glomerular Filtration Rate MeSH
- Cardio-Renal Syndrome blood etiology physiopathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Linear Models MeSH
- Multivariate Analysis MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
This prospective study evaluated the relationship between echocardiography parameters of left ventricular (LV) diastolic function and mild-to-moderate renal function impairment in 82 patients with type 2 diabetes mellitus. The mean age of the patients was 61.1 years. A significant correlation was found between estimated glomerular filtration rate (eGFR) and the ratio of peak velocity of early transmitral flow (E) to peak velocity of early diastolic mitral annular motion (E'). Cluster analysis revealed two subgroups of patients with different E' values but comparable eGFRs. The correlation between eGFR and E/E' was significant in 38 patients with E' ≤ 7.1 cm/s, but not significant in 44 patients with E' > 7.1 cm/s. The results suggest that the deterioration of LV relaxation (E') represents the underlying condition for the association between mild-to-moderate renal function impairment and the non-invasive parameter of LV end-diastolic pressure (E/E'), in patients with type 2 diabetes without any previous cardiovascular event and with well-controlled blood pressure.
- MeSH
- Demography MeSH
- Diabetes Mellitus, Type 2 physiopathology ultrasonography MeSH
- Diastole physiology MeSH
- Electrocardiography MeSH
- Ventricular Function, Left physiology MeSH
- Glomerular Filtration Rate physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Multivariate Analysis MeSH
- Aged MeSH
- Cluster Analysis MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
This study evaluated carotid artery parameters in normotensive patients with type 2 diabetes compared with non-diabetic control subjects. Using a high-resolution B-mode ultrasound scanner, common carotid artery intima-media thickness (IMT) and carotid tree atheroma thickness were measured in 82 patients with type 2 diabetes and 41 controls. The distensibility of the common carotid artery was calculated using the Reneman equation. Distensibility was significantly decreased and atheroma thickness was significantly increased in the diabetes group. There was no significant difference in IMT between the two groups. Stepwise linear regression analysis revealed an association between common carotid artery distensibility and post-ischaemic dilatation of the brachial artery (a measure of endothelial function), body mass index and diabetes duration in patients with type 2 diabetes. In conclusion, common carotid artery IMT in normotensive patients with type 2 diabetes is comparable to that of control subjects, whereas atheroma thickness is higher and arterial stiffness more pronounced in those with type 2 diabetes, indicating the existence of atherosclerotic changes in normotensive type 2 diabetes patients.
- MeSH
- Brachial Artery pathology ultrasonography MeSH
- Carotid Artery, Common pathology ultrasonography MeSH
- Atherosclerosis complications pathology ultrasonography MeSH
- Endothelium, Vascular pathology physiopathology MeSH
- Diabetes Mellitus, Type 2 complications pathology ultrasonography MeSH
- Body Mass Index MeSH
- Blood Pressure physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Carotid Artery Diseases complications pathology ultrasonography MeSH
- Tunica Intima pathology ultrasonography MeSH
- Tunica Media pathology ultrasonography MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
