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Autor
Aksenova, Marina 1 Ambarsari, Cahyani Gita 1 Awan, Atif 1 Becherucci, Francesca 1 Emma, Francesco 1 Fila, Marc 1 Francisco, Telma 1 Gokce, Ibrahim 1 Gülhan, Bora 1 Hansen, Matthias 1 Jahnukainen, Timo 1 Kallash, Mahmoud 1 Kamperis, Konstantinos 1 Mason, Sherene 1 Mastrangelo, Antonio 1 Mencarelli, Francesca 1 Niwinska-Faryna, Bogna 1 Pape, Lars 1 Riordan, Michael 1 Rus, Rina R 1
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Department of Pediatric Nephrology 2n... 1 Department of Pediatric Nephrology Aa... 1 Department of Pediatric Nephrology Az... 1 Department of Pediatric Nephrology Ba... 1 Department of Pediatric Nephrology Ci... 1 Department of Pediatric Nephrology Co... 1 Department of Pediatric Nephrology Do... 1 Department of Pediatric Nephrology Dr... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Fo... 1 Department of Pediatric Nephrology Ka... 1 Department of Pediatric Nephrology MH... 1 Department of Pediatric Nephrology Me... 1 Department of Pediatric Nephrology Mo... 1 Department of Pediatric Nephrology Na... 1 Department of Pediatric Nephrology St... 1
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Autor
Aksenova, Marina 1 Ambarsari, Cahyani Gita 1 Awan, Atif 1 Becherucci, Francesca 1 Emma, Francesco 1 Fila, Marc 1 Francisco, Telma 1 Gokce, Ibrahim 1 Gülhan, Bora 1 Hansen, Matthias 1 Jahnukainen, Timo 1 Kallash, Mahmoud 1 Kamperis, Konstantinos 1 Mason, Sherene 1 Mastrangelo, Antonio 1 Mencarelli, Francesca 1 Niwinska-Faryna, Bogna 1 Pape, Lars 1 Riordan, Michael 1 Rus, Rina R 1
- Organizace
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Department of Pediatric Nephrology 2n... 1 Department of Pediatric Nephrology Aa... 1 Department of Pediatric Nephrology Az... 1 Department of Pediatric Nephrology Ba... 1 Department of Pediatric Nephrology Ci... 1 Department of Pediatric Nephrology Co... 1 Department of Pediatric Nephrology Do... 1 Department of Pediatric Nephrology Dr... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Fo... 1 Department of Pediatric Nephrology Ka... 1 Department of Pediatric Nephrology MH... 1 Department of Pediatric Nephrology Me... 1 Department of Pediatric Nephrology Mo... 1 Department of Pediatric Nephrology Na... 1 Department of Pediatric Nephrology St... 1
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Free Medical Journals od 2011
PubMed Central od 2011
Europe PubMed Central od 2011
ProQuest Central od 2011-01-01
Open Access Digital Library od 2011-01-01
Open Access Digital Library od 2011-01-01
Nursing & Allied Health Database (ProQuest) od 2011-01-01
Health & Medicine (ProQuest) od 2011-01-01
Family Health Database (ProQuest) od 2011-01-01
Psychology Database (ProQuest) od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources od 2011
PubMed
34049919
DOI
10.1136/bmjopen-2020-047059
Knihovny.cz E-zdroje
BACKGROUND: Acute tubulointerstitial nephritis (TIN) is a significant cause of acute renal failure in paediatric and adult patients. There are no large paediatric series focusing on the aetiology, treatment and courses of acute TIN. PATIENTS, DESIGN AND SETTING: We collected retrospective clinical data from paediatric patients with acute biopsy-proven TIN by means of an online survey. Members of four professional societies were invited to participate. RESULTS: Thirty-nine physicians from 18 countries responded. 171 patients with acute TIN were included (54% female, median age 12 years). The most frequent causes were tubulointerstitial nephritis and uveitis syndrome in 31% and drug-induced TIN in 30% (the majority of these caused by non-steroidal anti-inflammatory drugs). In 28% of patients, no initiating noxae were identified (idiopathic TIN). Median estimated glomerular filtration rate (eGFR) rose significantly from 31 at time of renal biopsy to 86 mL/min/1.73 m2 3-6 months later (p<0.001). After 3-6 months, eGFR normalised in 41% of patients (eGFR ≥90 mL/min/1.73 m2), with only 3% having severe or end-stage impairment of renal function (<30 mL/min/1.73 m2). 80% of patients received corticosteroid therapy. Median eGFR after 3-6 months did not differ between steroid-treated and steroid-untreated patients. Other immunosuppressants were used in 18% (n=31) of patients, 21 of whom received mycophenolate mofetil. CONCLUSIONS: Despite different aetiologies, acute paediatric TIN had a favourable outcome overall with 88% of patients showing no or mild impairment of eGFR after 3-6 months. Prospective randomised controlled trials are needed to evaluate the efficacy of glucocorticoid treatment in paediatric patients with acute TIN.
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- dítě MeSH
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- intersticiální nefritida * MeSH
- lidé MeSH
- prospektivní studie MeSH
- průřezové studie MeSH
- retrospektivní studie MeSH
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- lidé MeSH
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