OBJECTIVE: To assess the association between newborn birth weight and the presence of intra-amniotic infection, presence of sterile intra-amniotic inflammation, and absence of intra-amniotic inflammation in pregnancies with preterm labor with intact membranes. METHODS: A total of 69 pregnancies with preterm labor with intact membranes between gestational ages 22 + 0 and 34 + 6 weeks who delivered within seven days of admission were included in this retrospective cohort study. Transabdominal amniocentesis to determine the presence of microorganisms and/or their nucleic acids in amniotic fluid (through culturing and molecular biology methods) and intra-amniotic inflammation (according to amniotic fluid interleukin-6 concentrations) were performed as part of standard clinical management. The participants were further divided into three subgroups: intra-amniotic infection (presence of microorganisms and/or nucleic acids along with intra-amniotic inflammation), sterile intra-amniotic inflammation (intra-amniotic inflammation alone), and without intra-amniotic inflammation. Birth weights of newborns were expressed as percentiles derived from the INTERGROWTH-21st standards for (i) estimated fetal weight and (ii) newborn birth weight. RESULTS: No difference in birth weights, expressed as percentiles derived from the standard for estimated fetal weight, was found among the women with intra-amniotic infection, with sterile intra-amniotic inflammation, and without intra-amniotic inflammation (with infection, median 29; with sterile inflammation, median 54; without inflammation, median 53; p = 0.06). Differences among the subgroups were identified in the birth weight rates, expressed as percentiles derived from the standard for estimated fetal weight, which were less than the 10th percentile (with infection: 20%, with inflammation: 13%, without inflammation: 0%; p = 0.04) and 25th percentile (with infection: 47%, with inflammation: 31%, without inflammation: 9%; p = 0.01). No differences among the subgroups were observed when percentiles of birth weight were derived from the birth weight standard. CONCLUSIONS: The presence of intra-amniotic inflammatory complications in pregnancies with preterm labor with intact membranes prior to the gestational age of 35 weeks was associated with a higher rate of newborns with birth weight less than the 10th and 25th percentile, when percentiles of birth weight were derived from the standard for estimated fetal weight.
- Publikační typ
- časopisecké články MeSH
Chitosan je málo toxický, neimunogenní a biologicky odbouratelný přírodní biopolymer. Jako deacetylovaná forma chitinu je ve velké míře používán v medicíně, zemědělství a průmyslu kvůli snadné výrobě, biokompatibilitě a antimikrobiální aktivitě. Chitosan je také široce studován jako hlavní stavební složka nanomateriálů. Četné studie prokázaly, že chitosan, kromě silných antibakteriálních účinků, lze využít jako adjuvans při konstrukci nových vakcín. Neméně významné je potenciální využití chitosanu jako nosiče xenobiotik. V tomto přehledu uvádíme základní informace o chitosanových nanočásticích, jejich přípravě, purifikaci a charakterizaci, stejně tak nová data o možnosti jejich využití pro přípravu směrovaných léčiv na bázi nanotechnologií.
Chitosan is low toxic, non-immunogenic and biodegradable natural biopolymer. As the deacetylated form of chitin, it is extensively used in medicine, agriculture and industry for easy production, biocompatibility and antimicrobial activity. Chitosan is also widely studied as the main structural unit of nanomaterials. Numerous studies have shown the strong antimicrobial activity of chitosan including its efficacy as an adjuvant for construction of new vaccines. In this overview, we present the basic information on chitosan nanopar-ticles, their preparation, purification, and characterization as well as the new data on their utilization for the construction of targetted drugs based on nanotechnologies.
- MeSH
- antigeny CD57 MeSH
- autoimunita MeSH
- buňky NK * fyziologie MeSH
- dengue MeSH
- HIV MeSH
- lidé MeSH
- nemoci centrálního nervového systému MeSH
- receptory buněk NK MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
