OBJECTIVE: To evaluate whether the amount of preoperative endometrial tissue surface is related to the degree of concordance with final low- and high-grade endometrial cancer (EC). In addition, to determine whether discordance is influenced by sampling method and impacts outcome. METHODS: A retrospective cohort study within the European Network for Individualized Treatment of Endometrial Cancer (ENITEC). Surface of preoperative endometrial tissue samples was digitally calculated using ImageJ. Tumor samples were classified into low-grade (grade 1-2 endometrioid EC (EEC)) and high-grade (grade 3 EEC + non-endometroid EC). RESULTS: The study cohort included 573 tumor samples. Overall concordance between pre- and postoperative diagnosis was 60.0%, and 88.8% when classified into low- and high-grade EC. Upgrading (preoperative low-grade, postoperative high-grade EC) was found in 7.8% and downgrading (preoperative high-grade, postoperative low-grade EC) in 26.7%. The median endometrial tissue surface was significantly lower in concordant diagnoses when compared to discordant diagnoses, respectively 18.7 mm2 and 23.5 mm2 (P = 0.022). Sampling method did not influence the concordance in tumor classification. Patients with preoperative high-grade and postoperative low-grade showed significant lower DSS compared to patients with concordant low-grade EC (P = 0.039). CONCLUSION: The amount of preoperative endometrial tissue surface was inversely related to the degree of concordance with final tumor low- and high-grade. Obtaining higher amount of preoperative endometrial tissue surface does not increase the concordance between pre- and postoperative low- and high-grade diagnosis in EC. Awareness of clinically relevant down- and upgrading is crucial to reduce subsequent over- or undertreatment with impact on outcome.
- MeSH
- biopsie metody MeSH
- endometrium patologie MeSH
- endometroidní karcinom * chirurgie patologie MeSH
- lidé MeSH
- nádory endometria * patologie MeSH
- retrospektivní studie MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Malignant pheochromocytoma is a tumour with a very low incidence that occurs sporadically or in the presence of multiple endocrine neoplasia. We present the case of a woman with a sporadic occurrence of pheochromocytoma diagnosed in the phase of multiple dissemination in the abdominal cavity and overexpressing adrenaline, noradrenaline, and dopamine. Local transarterial chemoembolization and systemic treatment with lanreotide resulted in a very good response, a decrease in the production of catecholamines for 12 months and a partial decrease for another 8 months, with stabilization of disease determined by imaging. Systemic treatment with tegafur resulted in disease stabilization lasting 50 months, after which the drug was discontinued because of adverse effects. Maintenance therapy with lanreotide continues, and no disease progression has been observed for 4 months. The treatment algorithm for such patients is multidisciplinary and must always take into account the current scope of the disease, intercurrence, and the general condition of the patient.
- Publikační typ
- časopisecké články MeSH
Prezentace dvou případů maligního fibrózního histiocytomu prsu – u 63leté ženy, kde se jednalo o myxoidní typ MFH, a u 79leté ženy s MFH pleiomorfního typu. Maligní fibrózní histiocytom je je- den z nejčastějších maligních tumorů měkkých tkání, jeho primární výskyt v mléčné žláze je však vzácný. Imunohistochemický průkaz antigenů v cytoplazmě histiocytů pomocí protilátky LN 5 (Anti-Macrofage, BioGenex) může pomoci ke stanovení správné diagnózy.
Two cases of malignant fibrous histiocytoma (MFH) of the breast are presented. The first case was a 63-year-old patient with MFH of myxoid type, the second case was a 79-year-old patient with MFH of pleiomorphic type. MFH is one of the most common tumors of the soft tissues, but its primary o- ccurrence in the breast is rare. Immunohistochemical detection of antigens in the cytoplasm of his- tiocytes by antibdy LN 5 (Anti-Macrophage, BioGenex) can be helpful in rendering of the right di- agnosis.
- MeSH
- biopsie metody využití MeSH
- časná diagnóza MeSH
- lidé MeSH
- mamografie metody využití MeSH
- nádory prsu diagnóza MeSH
- tenkojehlová biopsie metody využití MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kongresy MeSH
- MeSH
- biopsie sentinelové lymfatické uzliny MeSH
- karcinom diagnóza MeSH
- nádory prsu diagnóza MeSH
- Publikační typ
- kongresy MeSH
