- Publikační typ
- abstrakt z konference MeSH
Atypical myopathy (AM) is a potentially fatal disease of grazing horses. It is reportedly caused by the ingestion of sycamore seeds containing toxic hypoglycin A. In order to study metabolic changes, serum and urine samples from nine horses with atypical myopathy and 12 control samples from clinically healthy horses were collected and then analysed using a high-performance liquid chromatography coupled with tandem mass spectrometry; serum metabolic profiles as the disease progressed were also studied. Metabolic data were evaluated using unsupervised and supervised multivariate analyses. Significant differences were demonstrated in the concentrations of various glycine conjugates and acylcarnitines (C2-C26). Moreover, the concentrations of purine and pyrimidine metabolites, vitamins and their degradation products (riboflavin, trigonelline, pyridoxate, pantothenate), and selected organic and amino acids (aspartate, leucine, 2-oxoglutarate, etc.) were altered in horses with AM. These results represent a global view of altered metabolism in horses with atypical myopathy.
- MeSH
- biochemická analýza krve veterinární MeSH
- koně MeSH
- metabolom * MeSH
- moč chemie MeSH
- nemoci koní krev metabolismus moč MeSH
- nemoci svalů krev metabolismus moč veterinární MeSH
- sérum chemie MeSH
- tandemová hmotnostní spektrometrie veterinární MeSH
- vysokoúčinná kapalinová chromatografie veterinární MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- MeSH
- environmentální zdraví MeSH
- konzervace potravin normy MeSH
- školy normy MeSH
- stravovací služby normy MeSH
- Publikační typ
- přehledy MeSH
