Antiorthostatic hindlimb suspension (unloading) decreased the resting membrane potential (RMP) of skeletal muscle fibers in fast extensor digitorum longus (EDL) and slow soleus (SOL) muscle of the rat by about 10 % within 7 days and more. Inactivation of the membrane Na+, K+-pump by ouabain brought about similar depolarization as unloading. The increased sodium permeability of the membrane was excluded as the major cause of this depolarization by experiments in which TRIS was substituted for Na+ in the medium. On the other hand, the decrease in the electrogenic participation of the Na+,K+-pump is apparently one of the causes of RMP decrease during hypogravity, in EDL muscle in particular.

• MeSH
• financování organizované MeSH
• kosterní svaly metabolismus   MeSH
• krysa rodu rattus MeSH
• membránové potenciály fyziologie   MeSH
• potkani Wistar MeSH
• simulace stavu beztíže MeSH
• sodíko-draslíková ATPasa metabolismus   MeSH
• svalová kontrakce fyziologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH

• MeSH
• klasické podmiňování MeSH
• mozková kůra MeSH
• potkani Wistar MeSH
• thalamus MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• zvířata MeSH