1. elektronické vydání 1 online zdroj (420 stran)
Román o lásce a psaní ve věku digitálního smutku
První vydání 416 stran ; 21 cm
Reflexivní román o historii jednoho milostného vztahu je zároveň i "románem o románu o lásce" a o literární tvorbě.
A clinically relevant porcine model of a biofilm-infected wound was established in 10 minipigs. The wounds of six experimental animals were infected with a modified polymicrobial Lubbock chronic wound biofilm consisting of Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Bacillus subtilis. Four animals served as uninfected controls. The wounds were monitored until they had healed for 24 days. The biofilm persisted in the wounds up to day 14 and significantly affected healing. The control to infected healed wound area ratios were: 45%/21%, 66%/37%, and 90%/57% on days 7, 10 and 14, respectively. The implanted biofilm prolonged inflammation, increased necrosis, delayed granulation and impaired development of the extracellular matrix as seen in histological and gene expression analyses. This model provides a therapeutic one-week window for testing of anti-biofilm treatments and for research on the pathogenesis of wound infections in pig that is clinically the most relevant animal wound healing model.
- MeSH
- Bacillus subtilis růst a vývoj MeSH
- biofilmy růst a vývoj MeSH
- časové faktory MeSH
- Enterococcus faecalis růst a vývoj MeSH
- hojení ran * MeSH
- infekce v ráně farmakoterapie mikrobiologie MeSH
- modely nemocí na zvířatech * MeSH
- prasata MeSH
- Pseudomonas aeruginosa růst a vývoj MeSH
- Staphylococcus aureus růst a vývoj MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
We report a case of a 14-year-old patient with rare dorsal sternoclavicular dislocation caused by a sports injury. The patient was admitted to our department for further investigation and treatment. After a series of examinations, an open reduction and fixation using K-wires was used as a treatment modality. A satisfactory outcome was achieved, the patient returned to full sports activity 3 months after the surgery, with no limitations of movement. The necessity of early diagnosis and treatment options of this rare injury has been discussed. Key words: sternoclavicular joint, dorsal dislocation, open reduction.
UNLABELLED: PURPOSE OF THE STUDY This radiographic study was focused on measuring the dimensions of pelvic bones at sites of minimally invasive screw insertion with the aim to assess the risk of damage to vascular and nervous structures. MATERIAL AND METHODS The group consisted of 77 patients (39 women and 38 men) aged between 19 and 85 years (average, 65; women, 65; men, 64) who underwent CT examination of the pelvis because of reasons other than injury. On the left side, a total of 14 dimensions of the superior pubic ramus, supraacetabular region, retroacetabular region, quadrilateral surface of the acetabulum and lateral foraminal sides of the S1 and S2 vertebral bodies were measured. The results were evaluated using descriptive statistics. RESULTS The inner antero-posterior dimension of the isthmic area of the superior pubic ramus was 8 mm or less in four women (10.3%) and 9 or 10 mm in further 14 women (35.9%). The inner cranio-caudal dimension of the superior pubic ramus was 8 mm or less in 14 women (35.9%) and 9 or 10 mm in further 16 women (41.0%). These dimensions obtained in men were as follows: 8 mm and less in three men (7.9%) (7 mm in one, 8 mm in two), and 9 or 10 mm in nine men. Sizes of the other pelvic bones were large enough to allow for safe insertion of single screws. DISCUSSION Single screws most frequently used in minimally invasive treatment of pelvic fractures are cannulated screws 7.3 mm or 6.5 mm in diameter; less frequently used are 4.5-mm cancellous screws (e.g. in treatment of avulsion injuries) or long 3.5-mm cortical "creeping" screws to be inserted in the superior pubic ramus. The use of "creeping" screws reported by several authors indicates problems associated with placement of standard screws (diameter, 7.3 mm and 6.5 mm) through the isthmus into the superior ramus. In slim high pelvises of some patients with gracile skeletons or in low pelvises of small women, the screws can protrude over the cortical margin. However, the risk of injury to nervous or vascular structures is low when the intraosseous screw is exactly inserted and it is so even in case its thread cuts into cortical bone. Neither the femoral artery nor the femoral nerve is situated too close to the superior pubic ramus. The "corona mortis" may potentially be jeopardised because of its contact with both the superior and posterior cortical bones of the superior ramus, but it usually follows a course more lateral to the isthmus of the ramus. CONCLUSIONS The results of the study showed that the size of the superior pubic ramus in its isthmic area may cause difficulties during insertion of cannulated screws with standard diameters (7.3 mm and 6.5 mm) in the majority of women and in some men. The risk of damage to vascular and nervous structures during screw insertion is associated only with the superior and posterior walls of the superior pubic ramus and with the area of the S2 foramen in case the correct procedure of intraosseous screw insertion is not strictly followed. KEY WORDS: retrograde pubic screw, iliosacral screw, supraacetabular screw, retrograde posterior column screw.
- MeSH
- dospělí MeSH
- fraktury kostí chirurgie MeSH
- kostní šrouby MeSH
- lidé středního věku MeSH
- lidé MeSH
- miniinvazivní chirurgické výkony MeSH
- mladý dospělý MeSH
- pánevní kosti diagnostické zobrazování zranění MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- vnitřní fixace fraktury metody MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Román
2. vyd. 465 s. ; 21 cm
Rapidly growing mycobacteria (RGM) inhabit soil and water but certain strains represent a health risk for human and animals. Both clinical and soil RGM may be under selection pressure for resistance to tetracycline (TET) antibiotics, since tetracyclines are administrated to humans and farm animals, and TET residues enter soil through manuring; however, resistance to TET and the presence of TET-resistance genes have been assessed only in clinical isolates. We were therefore interested in comparing soil and clinical RGM in terms of TET resistance and the presence of TET-resistance genes. We used 44 RGM from grasslands with different exposure to animal manure, and 38 clinical RGM from Czech hospitals. There was no difference between the clinical and soil isolates in TET resistance, with >50% resistant isolates in both groups. otr(A), otr(B), tet(K), tet(L) or tet(M) were not detected in any soil or clinical isolate. In contrast, most isolates harbored tet(V) and tap, both encoding mycobacterial efflux pumps, including species where these genes have never been evidenced before. The phylogeny of tet(V) correlated with isolates' BOX-PCR profiles, suggesting that this gene evolved along with mycobacterial genomes as a part of the intrinsic resistome. In certain cases, tet(V) and/or tap were found in TET-sensitive isolates, or inversely, were not found in resistant strains. Concluding, intrinsic efflux pumps may be more important for TET resistance than horizontally transferred genes in both soil and clinical RGM. Their simple presence, however, does not attest to resistance, and therefore their diversity, function and expression merit further research.
- MeSH
- antibakteriální látky farmakologie MeSH
- bakteriální geny MeSH
- biologický transport genetika MeSH
- DNA fingerprinting MeSH
- mikrobiální testy citlivosti MeSH
- molekulární sekvence - údaje MeSH
- Mycobacteriaceae účinky léků genetika izolace a purifikace MeSH
- půdní mikrobiologie MeSH
- rezistence na tetracyklin genetika MeSH
- RNA ribozomální 16S genetika MeSH
- tetracyklin farmakologie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Klíčová slova
- invazívní mykotická onemocnění,
- MeSH
- amfotericin B * aplikace a dávkování MeSH
- dítě MeSH
- echinokandiny * aplikace a dávkování MeSH
- lidé MeSH
- lymfoblastická leukemie-lymfom z prekurzorových T-buněk * farmakoterapie komplikace MeSH
- mukormykóza * etiologie farmakoterapie chirurgie MeSH
- olecranon * mikrobiologie patologie účinky léků MeSH
- protokoly antitumorózní kombinované chemoterapie aplikace a dávkování imunologie škodlivé účinky MeSH
- recidiva * MeSH
- Rhizopus * izolace a purifikace klasifikace účinky léků MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- práce podpořená grantem MeSH
1. elektronické vydání 1 online zdroj (148 stran)
Kniha je určená všem pamětníkům, zájemcům o motorismus a jeho historii. Publikace představí Albina Liebische (1888-1965), který je bezesporu jedním z mála sudetských Němců, kterému byla Čechy odhalena pamětní deska. Liebischovy motocykly Čechie-Böhmerland se staly pojmem a jsou to dodnes nejdelší motocykly na světě. Jejich neortodoxní zjev již více než osmdesát let ohromuje světovou motoristickou veřejnost, inspiruje umělce a pudí historiky techniky a nejrůznější publicisty k sepisování článků a studií nejrůznější úrovně. Dlouholetý sběr informací umožnil autorovi vypsat životní peripetie Albina Liebische, pro něhož, jak po letech vzpomínal jeho syn Richard, nebylo nic nemožné. Patnáct let - až do začátku 2. světové války - dokázal se svou malou firmou pomocí minimalistických marketingových metod prodávat unikátní motocykl téměř komukoliv.
