INTRODUCTION: One of the most debilitating problems encountered by people with multiple sclerosis (MS) is the loss of balance and coordination. Our study aimed to comprehensively evaluate the effectiveness of one year of Tai-chi exercise in patients with MS using both subjective and objective methods, including posturography. METHODS: This was a single-group longitudinal one-year study performed from the 1st of January 2019 to the 1st of January 2020. The primary outcomes of interest were the Mini-Balance Evaluation Systems Test (Mini-BESTest) and static posturography measures as objective methods to detect subtle changes associated with postural control/balance impairment. Secondary outcomes were measures of depression, anxiety, cognitive performance, and quality of life. All objective and subjective parameters were assessed four times: at baseline, and after three, six and 12 months of regular Tai-chi training. The difference was calculated as a subtraction of baseline values from every timepoint value for each measurement. If the normality test was passed, parametric one-sample t-test was used, if failed, Wilcoxon signed ranks test was used to test the difference between the baseline and each timepoint. Alpha was set to 0.017 using Bonferroni correction for multiple comparisons. RESULTS: Out of 25 patients with MS enrolled, 15 women with MS (mean age 44.27 years) were included for statistical analyses after completing the 12-month program. After 12 months, significant improvements were found in all objective balance and gait tests: Mini-BESTest (p<0.001), static posturography measures (total area of the centre of foot pressure - TA; p = 0.015), 25 Feet Walk Test (25FWT; p = 0.001), anxiety (Beck Anxiety Inventory - BAI; p = 0.005) and cognition tests (Paced Auditory Serial Addition Test - PASAT; p = 0.003). Measures of depression (Beck Depression Inventory - BDI; p = 0.071), cognition (Symbol Digit Modalities Test - SDMT; p = 0.079), and health-related quality of life (European Quality of Life 5-Dimensions Questionnaire - EQ-5D-5L; p = 0.095) showed a trend of improvement but were not significant, which could be the result of a small sample and increased bias due the type II error. CONCLUSION: According to these preliminary results, this study indicates the possible beneficial effects of long-term Tai-chi training on patients with MS. Although these findings need to be confirmed by further studies with a larger sample of participants of both genders and require more rigorous randomized controlled trials (RCT) design, our findings support the recommendation of regular and long-term Tai-chi exercise in patients with MS. GOV IDENTIFIER (RETROSPECTIVELY REGISTERED): NCT05474209.
- MeSH
- dospělí MeSH
- kognice MeSH
- kvalita života MeSH
- lidé MeSH
- posturální rovnováha MeSH
- prospektivní studie MeSH
- roztroušená skleróza * komplikace terapie MeSH
- taiči * MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Diabetes mellitus je chronické metabolické ochorenie so stále stúpajúcou prevalenciou. Nedostatočná kompenzácia diabetes mellitus vedie ku vzniku komplikácií, ktoré zahŕňajú okrem iného polyneuropatie, retinopatie, vestibulárne dysfunkcie a encefalopatie. Tie môžu mať za následok poruchy rovnováhy. Instabilita postoja a chôdze vedie k rekurentným pádom, ktoré významne zhoršujú kvalitu života pacientov a komplikáciami zaťažujú zdravotný systém. V manažmente posturálnej instability je najdôležitejšia precízna kontrola samotného ochorenia a cielená rehabilitácia postoja a chôdze.
Diabetes mellitus is a chronic metabolic disease with an ever-increasing prevalence. Inadequate compensation of diabetes mellitus leads to the development of complications which, among other complaints, include polyneuropathy, retinopathy, vestibular dysfunctions and encephalopathy. These may result in balance disorders. Instability of posture and gait leads to recurrent falls which significantly reduce patients´ quality of life and burden the health care system due to complications. Within the management of postural instability precise control of the disease itself is most important, as well as targeted rehabilitation of posture and gait.
- MeSH
- diabetes mellitus * MeSH
- diabetická retinopatie patologie MeSH
- diabetické neuropatie diagnóza etiologie patofyziologie MeSH
- komplikace diabetu MeSH
- lidé MeSH
- nemoci mozku diagnóza MeSH
- pohybová aktivita MeSH
- úrazy pádem MeSH
- vestibulární aparát * patofyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- MeSH
- lidé MeSH
- postura těla MeSH
- vestibulární aparát fyziologie MeSH
- Check Tag
- lidé MeSH
