Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic RNA surveillance mechanism that degrades aberrant mRNAs. NMD impairment in Arabidopsis is linked to constitutive immune response activation and enhanced antibacterial resistance, but the underlying mechanisms are unknown. Here we show that NMD contributes to innate immunity in Arabidopsis by controlling the turnover of numerous TIR domain-containing, nucleotide-binding, leucine-rich repeat (TNL) immune receptor-encoding mRNAs. Autoimmunity resulting from NMD impairment depends on TNL signaling pathway components and can be triggered through deregulation of a single TNL gene, RPS6. Bacterial infection of plants causes host-programmed inhibition of NMD, leading to stabilization of NMD-regulated TNL transcripts. Conversely, constitutive NMD activity prevents TNL stabilization and impairs plant defense, demonstrating that host-regulated NMD contributes to disease resistance. Thus, NMD shapes plant innate immunity by controlling the threshold for activation of TNL resistance pathways.
- MeSH
- Arabidopsis genetika imunologie mikrobiologie MeSH
- interakce hostitele a patogenu MeSH
- messenger RNA genetika imunologie MeSH
- nemoci rostlin genetika imunologie mikrobiologie MeSH
- nesmyslný kodon MeSH
- nonsense mediated mRNA decay * MeSH
- proteiny huseníčku genetika imunologie MeSH
- Pseudomonas syringae genetika fyziologie MeSH
- receptory imunologické genetika imunologie MeSH
- RNA-helikasy genetika imunologie MeSH
- transportní proteiny genetika imunologie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
