-
Autor
Adami, Hans-Olov 1 Ansell, Stephen M 1 Bassig, Bryan A 1 Becker, Nikolaus 1 Benavente, Yolanda 1 Berndt, Sonja I 1 Besson, Caroline M 1 Birmann, Brenda M 1 Boffetta, Paolo 1 Bracci, Paige M 1 Brennan, Paul 1 Brown, Elizabeth E 1 Burdette, Laurie 1 Canzian, Federico 1 Caporaso, Neil E 1 Cerhan, James R 1 Chanock, Stephen J 1 Chatterjee, Nilanjan 1 Chung, Charles C 1 Clavel, Jacqueline 1
-
Pracoviště
Bill Lyons Informatics Centre UCL Can... 1 Cancer Biology and Genetics Program M... 1 Cancer Epidemiology Research Programm... 1 Cancer Epidemiology Unit University o... 1 Cancer Genomics Research Laboratory L... 1 Center for Chronic Immunodeficiency U... 1 Centre for Big Data Research in Healt... 1 Channing Division of Network Medicine... 1 Channing Division of Network Medicine... 1 Department of Cancer Epidemiology and... 1 Department of Computational Biology S... 1 Department of Environmental Health Sc... 1 Department of Epidemiology Brown Univ... 1 Department of Epidemiology Harvard T ... 1 Department of Epidemiology School of ... 1 Department of Epidemiology School of ... 1 Department of Epidemiology University... 1 Department of Epidemiology and Biosta... 1 Department of Family Medicine and Pub... 1 Department of Health Sciences Researc... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
-
Autor
Adami, Hans-Olov 1 Ansell, Stephen M 1 Bassig, Bryan A 1 Becker, Nikolaus 1 Benavente, Yolanda 1 Berndt, Sonja I 1 Besson, Caroline M 1 Birmann, Brenda M 1 Boffetta, Paolo 1 Bracci, Paige M 1 Brennan, Paul 1 Brown, Elizabeth E 1 Burdette, Laurie 1 Canzian, Federico 1 Caporaso, Neil E 1 Cerhan, James R 1 Chanock, Stephen J 1 Chatterjee, Nilanjan 1 Chung, Charles C 1 Clavel, Jacqueline 1
-
Pracoviště
Bill Lyons Informatics Centre UCL Can... 1 Cancer Biology and Genetics Program M... 1 Cancer Epidemiology Research Programm... 1 Cancer Epidemiology Unit University o... 1 Cancer Genomics Research Laboratory L... 1 Center for Chronic Immunodeficiency U... 1 Centre for Big Data Research in Healt... 1 Channing Division of Network Medicine... 1 Channing Division of Network Medicine... 1 Department of Cancer Epidemiology and... 1 Department of Computational Biology S... 1 Department of Environmental Health Sc... 1 Department of Epidemiology Brown Univ... 1 Department of Epidemiology Harvard T ... 1 Department of Epidemiology School of ... 1 Department of Epidemiology School of ... 1 Department of Epidemiology University... 1 Department of Epidemiology and Biosta... 1 Department of Family Medicine and Pub... 1 Department of Health Sciences Researc... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
PubMed
30305637
DOI
10.1038/s41467-018-06541-2
Knihovny.cz E-zdroje
Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40-31.03, P = 1.36 × 10-54) and 14q32.13 (rs117410836, near TCL1; OR = 4.90, 95% CI: 3.45-6.96, P = 8.75 × 10-19). Both risk alleles are observed at a low frequency among controls (~2-3%) and occur in excess in affected cases within families. In silico data suggest that rs116446171 may have functional importance, and in functional studies, we demonstrate increased reporter transcription and proliferation in cells transduced with the 6p25.3 risk allele. Although further studies are needed to fully elucidate underlying biological mechanisms, together these loci explain 4% of the familial risk and provide insights into genetic susceptibility to this malignancy.
- MeSH
- anotace sekvence MeSH
- genetická predispozice k nemoci * MeSH
- genotypizační techniky MeSH
- HEK293 buňky MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé MeSH
- lidské chromozomy, pár 14 genetika MeSH
- lidské chromozomy, pár 6 genetika MeSH
- mikro RNA metabolismus MeSH
- proliferace buněk MeSH
- reportérové geny MeSH
- reprodukovatelnost výsledků MeSH
- rizikové faktory MeSH
- rodina MeSH
- sekvence nukleotidů MeSH
- typy dědičnosti genetika MeSH
- Waldenströmova makroglobulinemie genetika MeSH
- zelené fluorescenční proteiny metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Upřesnit dle MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.