Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.
- MeSH
- Clausena chemie MeSH
- furokumariny biosyntéza farmakologie MeSH
- kumariny chemie MeSH
- léčivé rostliny chemie MeSH
- lidé MeSH
- rostlinné extrakty metabolismus farmakologie MeSH
- Ruta chemie MeSH
- Rutaceae chemie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- MeSH
- Coffea účinky léků MeSH
- homeopatie MeSH
- lidé MeSH
- Rheum účinky léků MeSH
- Ruta účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- Aedes imunologie účinky léků virologie MeSH
- arnika účinky léků MeSH
- Atropa belladonna účinky léků MeSH
- lidé MeSH
- Rhus účinky léků MeSH
- Ruta účinky léků MeSH
- virus chikungunya imunologie účinky léků MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Indický oceán MeSH
- Mauricius MeSH
