- MeSH
- cukry škodlivé účinky MeSH
- gingivitida dietoterapie prevence a kontrola MeSH
- lidé MeSH
- nutriční terapie * metody MeSH
- omega-3 mastné kyseliny MeSH
- parodontitida * dietoterapie prevence a kontrola MeSH
- potravní vláknina MeSH
- stravovací zvyklosti MeSH
- zdravá strava metody MeSH
- živiny terapeutické užití MeSH
- Check Tag
- lidé MeSH
OBJECTIVE: The aim of this study was to: (1) evaluate the anti-inflammatory effects of cannabidiol (CBD) on primary cultures of human gingival fibroblasts (HGFs) and (2) to clinically monitor the effect of CBD in subjects with periodontitis. BACKGROUND: The use of phytocannabinoids is a new approach in the treatment of widely prevalent periodontal disease. MATERIALS AND METHODS: Cannabinoid receptors were analyzed by western blot and interleukin production detected using enzyme immunoassay. Activation of the Nrf2 pathway was studied via monitoring the mRNA level of heme oxygenase-1. Antimicrobial effects were determined by standard microdilution and 16S rRNA screening. In the clinical part, a placebo-control double-blind randomized study was conducted (56 days) in three groups (n = 90) using dental gel without CBD (group A) and with 1% (w/w) CBD (group B) and corresponding toothpaste (group A - no CBD, group B - with CBD) for home use to maintain oral health. Group C used dental gel containing 1% chlorhexidine digluconate (active comparator) and toothpaste without CBD. RESULTS: Human gingival fibroblasts were confirmed to express the cannabinoid receptor CB2. Lipopolysaccharide-induced cells exhibited increased production of pro-inflammatory IL-6 and IL-8, with deceasing levels upon exposure to CBD. CBD also exhibited antimicrobial activities against Porphyromonas gingivalis, with an MIC of 1.5 μg/mL. Activation of the Nrf2 pathway was also demonstrated. In the clinical part, statistically significant improvement was found for the gingival, gingival bleeding, and modified gingival indices between placebo group A and CBD group B after 56 days. CONCLUSIONS: Cannabidiol reduced inflammation and the growth of selected periodontal pathogenic bacteria. The clinical trial demonstrated a statistically significant improvement after CBD application. No adverse effects of CBD were reported by patients or observed upon clinical examination during the study. The results are a promising basis for a more comprehensive investigation of the application of non-psychotropic cannabinoids in dentistry.
- MeSH
- antiflogistika terapeutické užití farmakologie MeSH
- chlorhexidin terapeutické užití farmakologie analogy a deriváty MeSH
- dospělí MeSH
- dvojitá slepá metoda MeSH
- faktor 2 související s NF-E2 MeSH
- fibroblasty * účinky léků MeSH
- gingiva * účinky léků MeSH
- gingivitida * farmakoterapie MeSH
- hemoxygenasa-1 MeSH
- interleukin-6 analýza MeSH
- interleukin-8 účinky léků MeSH
- kanabidiol * farmakologie terapeutické užití MeSH
- kultivované buňky MeSH
- lidé středního věku MeSH
- lidé MeSH
- parodontitida farmakoterapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
- MeSH
- dospělí MeSH
- gingivitida patologie terapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- ortodontická extruze * metody MeSH
- rentgendiagnostika panoramatická metody MeSH
- stomatologická protetika * metody přístrojové vybavení MeSH
- výsledek terapie MeSH
- zubní kaz patologie terapie MeSH
- zubní materiály MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
BACKGROUND: Plaque-induced gingivitis is the most prevalent periodontal disease associated with pathogenic biofilms. The host immune system responds to pathogens through pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and their co-receptor cluster of differentiation 14 (CD14). AIM: This study investigated the association between the functional polymorphism in the CD14 gene and the dental plaque microbiota in children with gingivitis. DESIGN: A total of 590 unrelated children (307 with plaque-induced gingivitis and 283 controls, aged 13-15 years) were enrolled in this case-control study. Dental plaque was processed using a ParoCheck® 20 detection kit. The CD14 -260C/T (rs2569190) polymorphism was determined with the PCR-RFLP method. RESULTS: Gingivitis was detected in 64.2% of boys and 35.8% of girls (P < .001). Children with gingivitis had a significantly higher occurrence of dental caries (P < .001). No significant differences in the CD14 -260C/T allele and genotype distribution among individuals with or without gingivitis in the whole cohort were found. Children with gingivitis and P gingivalis, however, were significantly more frequent carriers of the CT and TT genotypes than children with gingivitis without P gingivalis or healthy controls (P < .05). CONCLUSIONS: The CD14 -260C/T polymorphism acts in cooperation with P gingivalis to trigger plaque-induced gingivitis in Czech children.
- MeSH
- dítě MeSH
- gingivitida * genetika MeSH
- lidé MeSH
- lipopolysacharidové receptory * MeSH
- mladiství MeSH
- polymorfismus genetický MeSH
- Porphyromonas gingivalis MeSH
- studie případů a kontrol MeSH
- zubní kaz * MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Plaque-induced gingivitis is the most prevalent periodontal disease associated with pathogenic biofilms. The host immune system responds to pathogens through pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and their co-receptor cluster of differentiation 14 (CD14). AIM: This study investigated the association between the functional polymorphism in the CD14 gene and the dental plaque microbiota in children with gingivitis. DESIGN: A total of 590 unrelated children (307 with plaque-induced gingivitis and 283 controls, aged 13-15 years) were enrolled in this case-control study. Dental plaque was processed using a ParoCheck® 20 detection kit. The CD14 -260C/T (rs2569190) polymorphism was determined with the PCR-RFLP method. RESULTS: Gingivitis was detected in 64.2% of boys and 35.8% of girls (P < .001). Children with gingivitis had a significantly higher occurrence of dental caries (P < .001). No significant differences in the CD14 -260C/T allele and genotype distribution among individuals with or without gingivitis in the whole cohort were found. Children with gingivitis and P gingivalis, however, were significantly more frequent carriers of the CT and TT genotypes than children with gingivitis without P gingivalis or healthy controls (P < .05). CONCLUSIONS: The CD14 -260C/T polymorphism acts in cooperation with P gingivalis to trigger plaque-induced gingivitis in Czech children.
- MeSH
- dítě MeSH
- gingivitida * genetika MeSH
- lidé MeSH
- lipopolysacharidové receptory * MeSH
- mladiství MeSH
- polymorfismus genetický MeSH
- Porphyromonas gingivalis MeSH
- studie případů a kontrol MeSH
- zubní kaz * MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- antibakteriální látky terapeutické užití MeSH
- diferenciální diagnóza MeSH
- extrakce zubů škodlivé účinky MeSH
- gingivitida diagnóza komplikace MeSH
- granulomatóza s polyangiitidou * diagnostické zobrazování farmakoterapie komplikace MeSH
- hormony kůry nadledvin terapeutické užití MeSH
- lidé středního věku MeSH
- lidé MeSH
- neúspěšná terapie MeSH
- pankreas diagnostické zobrazování patologie MeSH
- PET/CT MeSH
- sinusitida diagnostické zobrazování komplikace patologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- Publikační typ
- kazuistiky MeSH
1. vydání 24 nečíslovaných stran : ilustrace ; 28 cm
Atlas a příručka se zaměřuje na špatné a správné metody čištění zubů dětí. Obsahuje reklamu na zubní pasty a kartáčky. Určeno rodičům.
- MeSH
- čištění zubů metody MeSH
- dítě MeSH
- gingivitida prevence a kontrola MeSH
- orální zdraví MeSH
- péče o dítě MeSH
- rodiče MeSH
- vzdělávání pacientů jako téma MeSH
- zdraví dítěte MeSH
- zdravotní výchova zubní MeSH
- zubní kaz prevence a kontrola MeSH
- zubní pasty MeSH
- zubní prostředky domácí MeSH
- Check Tag
- dítě MeSH
- Publikační typ
- atlasy MeSH
- inzerce MeSH
- populární práce MeSH
- příručky MeSH
- Konspekt
- Pediatrie
- NLK Obory
- pediatrie
- zubní lékařství
- preventivní medicína
Oral health is important not only due to the diseases emerging in the oral cavity but also due to the direct relation to systemic health. Thus, early and accurate characterization of the oral health status is of utmost importance. There are several salivary biomarkers as candidates for gingivitis and periodontitis, which are major oral health threats, affecting the gums. These need to be verified and validated for their potential use as differentiators of health, gingivitis and periodontitis status, before they are translated to chair-side for diagnostics and personalized monitoring. We aimed to measure 10 candidates using high sensitivity ELISAs in a well-controlled cohort of 127 individuals from three groups: periodontitis (60), gingivitis (31) and healthy (36). The statistical approaches included univariate statistical tests, receiver operating characteristic curves (ROC) with the corresponding Area Under the Curve (AUC) and Classification and Regression Tree (CART) analysis. The main outcomes were that the combination of multiple biomarker assays, rather than the use of single ones, can offer a predictive accuracy of > 90% for gingivitis versus health groups; and 100% for periodontitis versus health and periodontitis versus gingivitis groups. Furthermore, ratios of biomarkers MMP-8, MMP-9 and TIMP-1 were also proven to be powerful differentiating values compared to the single biomarkers.
- MeSH
- biologické markery metabolismus MeSH
- dospělí MeSH
- ELISA metody MeSH
- gingivitida diagnóza metabolismus MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- matrixová metaloproteinasa 8 metabolismus MeSH
- matrixová metaloproteinasa 9 metabolismus MeSH
- orální zdraví * MeSH
- parodontitida diagnóza metabolismus MeSH
- plocha pod křivkou MeSH
- průřezové studie MeSH
- ROC křivka MeSH
- sliny metabolismus MeSH
- studie případů a kontrol MeSH
- tkáňový inhibitor metaloproteinasy 1 metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Zápalové zmeny a ulcerácie sliznice dutiny ústnej môžu byť spôsobené infekciami, iritačnými, chemickými a fyzikálnymi faktormi, liekmi, alebo sú prejavom systémového ochorenia. Ide o multidisciplinárnu problematiku. Často je nutná spolupráca dermatológa, stomatológa a prípadne otorinolaryngológa. V texte je podaný prehľad základných zápalových ochorení v dutine ústnej a možnosti ich liečby.
Inflammatory oral cavity diseases may be caused by infections, irritation, chemical and physical factors and some drugs, or they can occur as a manifestation of a systemic disease. This issue represents a typical interdisciplinary problem and a cooperation among a dermatologist, a dentist and sometimes an otorhinolaryngologist is necessary. In the article, an overview of oral cavity inflammatory diseases possible treatment is described.
- MeSH
- Behcetův syndrom diagnóza MeSH
- cheilitida diagnóza etiologie klasifikace terapie MeSH
- diferenciální diagnóza MeSH
- gingivitida etiologie klasifikace terapie MeSH
- glositida diagnóza etiologie MeSH
- lidé MeSH
- Sjögrenův syndrom diagnóza MeSH
- stomatitida diagnóza etiologie terapie MeSH
- ústní sliznice * patologie MeSH
- ústní symptomy MeSH
- xerostomie MeSH
- Check Tag
- lidé MeSH
