Stastny, P, Lehnert, M, De Ste Croix, M, Petr, M, Svoboda, Z, Maixnerova, E, Varekova, R, Botek, M, Petrek, M, Lenka, K, and Cięszczyk, P. Effect of COL5A1, GDF5, and PPARA genes on a movement screen and neuromuscular performance in adolescent team sport athletes. J Strength Cond Res 33(8): 2057-2065, 2019-The risk of injury increases with adolescents' chronological age and may be related to limited muscle function neuromuscular, genetic, and biomechanical factors. The purpose of this study was to determine whether COL5A1, PPARA, and GDF5 genes are associated with muscle functions and stretch-shortening cycle performance in adolescent athletes. One hundred forty-six youth players (14.4 ± 0.2 years) from various team sports (basketball n = 54, soccer n = 50, handball n = 32) underwent a manual test for muscle function, maturity estimation, functional bend test (FBT), passive straight leg raise (SLR) test, leg stiffness test, test of reactive strength index (RSI), and gene sampling for COL5A1, PPARA, and GDF5. The χ test did not show any differences in allele or genotype frequency between participants before and after peak height velocity. Multivariate analysis of variance showed that COL5A1 rs12722 CT heterozygotes had worse score in FBT (p < 0.001), worse score in SLR (p = 0.003), and lower maturity offset (p = 0.029, only in females) than TT homozygotes. Male GDF5 rs143383 GG homozygotes showed better score in SLR than AA and AG genotypes (p = 0.003), and AA and AG genotypes in both sex had greater RSI than GG homozygotes (p = 0.016). The PPARA rs4253778 CC homozygotes had greater RSI than GG and GC genotypes (p = 0.004). The CT genotype in COL5A1 rs12722 is possible predictor of functional movement disruption in the posterior hip muscle chain, causing shortening in FBT and SLR, which includes hamstrings function. CT genotype in COL5A1 rs12722 should be involved in programs targeting hamstring and posterior hip muscle chain.

• MeSH
• biomechanika MeSH
• genotyp MeSH
• kolagen typ V genetika   MeSH
• kosterní svaly metabolismus   MeSH
• lidé MeSH
• mladiství MeSH
• pohyb fyziologie   MeSH
• PPAR alfa genetika   MeSH
• průřezové studie MeSH
• puberta fyziologie   MeSH
• růstový diferenciační faktor 5 genetika   MeSH
• sexuální faktory MeSH
• sport pro děti a mládež fyziologie   MeSH
• sportovci * MeSH
• svalová síla MeSH
• tělesné váhy a míry MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Bude sledován obsah a aktivita želazináz a hladina solubilních forem imunoglobulinů ICAM-1 a VCAM-1 v krevním séru a v synoviální tekutině pacientů s časnou revmatoidní artritidou. V daném materiálu bude korelován obsak a aktivita želatináz s hladinami s-ICAM-1 a s-VCAM 1 a s aktuálním klinickým stavem.; A study will be made of the content and activity of gelatinase B and the levels of the soluble forms of immunoglobulins ICAM-1 and VCAM-1 in the blood serum and in the synovial fluid of patients with early rheumatoid arthritis. In the material a correlation will be drawn between the content and activity of gelatinase B and the levels of s ICAM-1 and sVCAM-1 and the levels of sICAM-1 and sVC.

• MeSH
• cévní buněčněadhezivní molekula-1 krev   MeSH
• kolagen typ V MeSH
• kolagenasy analýza   MeSH
• mezibuněčná adhezivní molekula-1 krev   MeSH
• prognóza MeSH
• revmatoidní artritida diagnóza   MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• revmatologie
• biochemie
• NLK Publikační typ
• závěrečné zprávy o řešení grantu IGA MZ ČR