Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.
- MeSH
- beta-katenin * MeSH
- křemík farmakologie MeSH
- kyselina křemičitá farmakologie MeSH
- lithium farmakologie MeSH
- myši MeSH
- nanodráty * MeSH
- poréznost MeSH
- zubní cement (tkáň) MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- extrakce zubů MeSH
- lidé MeSH
- rentgendiagnostika zubní MeSH
- senioři MeSH
- zubní cement (tkáň) * patologie MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
OBJECTIVE: Mesiodens is the most common form of supernumerary tooth mainly located between the maxillary central incisors. Its etiology is not completely understood but both genetic and environmental factors are assumed. The degree of mineralization and inorganic element content in hard tooth tissues is poorly understood as well as is the durability and suitability for allo- and auto-transplantation. Therefore aim of this study was to examine the content of inorganic elements. MATERIALS AND METHODS: This study included 26 mesiodens teeth and 26 normal central incisor teeth as controls. All specimens were prepared for SEM/EDS analysis which was aimed at specific sites on the enamel, dentine and cementum in order to evaluate the weight percentage and ratio of important inorganic elements. RESULTS: and Conclusion. The results showed that there was a difference in the weight percentage of selected inorganic elements (calcium, phosphorus, oxygen, carbon, magnesium and sodium) in all three types of dental hard tissues but the differences were mostly expressed in the cementum tissue. The statistical analysis showed that the differences were marginally significant especially for calcium and phosphorus values and ratio in the enamel and dentine. The carbon and magnesium content in all three hard tissues showed the most differences, but overall, the hard tissues mineral content of the mesiodens did not differs significantly from healthy teeth.
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- dentin chemie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- minerály analýza MeSH
- prvky * MeSH
- spektrometrie rentgenová emisní MeSH
- studie případů a kontrol MeSH
- zubní cement (tkáň) chemie MeSH
- zubní sklovina chemie MeSH
- zuby přespočetné metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Úvod a cieľ: Hlavným cieľom tohto prehľadového článku je detailný popis jednotlivých štruktúr zuba, bioorganického a bioanorganického zloženia častí zuba, jednotlivých biochemických protektívnych procesov, akými sa zub dokáže chrániť proti vzniku zubného kazu a procesov poškodzujúcich integritu zuba. V ďalšej časti je popísaný vplyv jednotlivých chemických prvkov z potravy, ktoré sa podieľajú na pevnejšej štruktúre zubov a zvyšovaní odolnosti zubov na vplyv kyselín. Metódy: Analýza zloženia zubov, porovnávanie vplyvu rôznych chemických prvkov zo stravy. Výsledky: Obranyschopnosť skloviny zvyšuje vhodná štruktúra a biochemické zloženie, a to hlavne tým, že každý sklovinný kryštál je obalený plášťom, tzv. rod sheath, ktorý je viac mineralizovaný ako ostatné vrstvy skloviny. Táto štruktúra obsahuje železo a horčík. Kombinácia týchto dvoch prvkov dodáva sklovine požadovanú odolnosť voči kyselinám. Dôležitú úlohu majú v sklovine aj proteíny. Proteíny spevňujú sklovinu a regulujú vývoj kryštálov hydroxyapatitu. Pre zachovanie zdravých zubov a hlavne skloviny sú potrebné viaceré prvky (bór, kremík, vápnik, horčík, fosfor), vitamíny (D, K) a živočíšne proteíny, ktoré zvyšujú absorpciu vápnika a horčíka. Vzácne kovy pôsobia dezinfekčne a antioxidačne (striebro, zlato, platina). Na druhej strane existujú látky, ktoré zdravie zubov poškodzujú. Sú to najmä kyselina fytová, kyselina šťaveľová, kyselina citrónová a zvýšené množstvo sacharidov a tukov znižujú resorpciu vápnika. Olovo vytesňuje vápnik zo štruktúry zuba a lektíny bránia vstrebávaniu pre zuby potrebných živín. Záver: Táto práca detailne popisuje jednotlivé zložky zuba, jeho bioanorganické aj bioorganické zloženie. Bioorganická časť má vo vysoko mineralizovanom zube významnú úlohu pri zachovávaní integrity zuba. Správna kombinácia prvkov, vitamínov pochádzajúcich z pestrej stravy a pobytu na slnku sa podieľa na udržaní zdravých zubov.
Introduction and objectives: The main objective of this review article is a detailed description of the tooth structure, bioorganic and bioinorganic composition of the tooth components, the protective biochemical process of tooth which can protect against tooth caries and processes which might damage the integrity of the tooth. The next section of this work describes the effect of various dietary chemical elements which are involved in the stronger teeth structure and increase the resistance of teeth against the effect of acids. Methods: Analysis of teeth composition, comparison of different chemical elements from diet. Results: Defense capability of enamel enhances suitable enamel structure and biochemical composition, especially the fact that each enamel crystal is covered with shell „rod sheath“ that is more mineralized than the other layers of enamel. This structure contains iron and magnesium. The combination of these two elements gives the enamel a desired resistance to acids. Enamel proteins play an important role in the enamel. Proteins strengthen a enamel and regulate the development of hydroxyapatite crystals. For maintaining healthy teeth and mainly the enamel are needed several chemical elements (boron, silicon, calcium, magnesium, phosphorus), vitamins (D, K) and animal proteins, which enhances the absorption of calcium and magnesium. Noble metals (silver, gold, platinum) act as antiseptic and antioxidant elements. On the other hand, there are substances which damages the health of teeth, especially phytic acid, oxalic acid, citric acid, increased amount of saccharides and fats reduce the resorption of calcium. Lead displaces calcium from the tooth structure and lectins interfere with the absorption of nutrients needed for teeth. Conclusion: This work describes in detail the individual components of tooth and bioorganic and bioinorganic composition of tooth. Bioorganic part showed in highly mineralized tooth important role in maintaining the integrity of the tooth. The right combination of elements, vitamins from varied diet and sun exposure contribute to maintaining healthy teeth.
- MeSH
- biochemie * MeSH
- hydroxyapatit analýza MeSH
- lidé MeSH
- minerály MeSH
- proteiny fyziologie klasifikace MeSH
- strava, jídlo, výživa MeSH
- vitaminy MeSH
- zubní cement (tkáň) MeSH
- zubní dřeň MeSH
- zubní kaz prevence a kontrola MeSH
- zubní sklovina anatomie a histologie fyziologie MeSH
- zuby * anatomie a histologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
This article aims to share the results of research conducted in the Fergana chemical plant of furan compounds (FCPFC) in Uzbekistan.19 workers of the Furan compounds plant, in Fergana, Uzbekistan, were tested. By neutron activation analysis method, we have studied microelement composition of saliva, blood, dental hard tissue, and the level of Ca, Zn, Fe, and Ag in these subjects. We have detected that the level of chemical elements in dental hard tissue, blood, and saliva of these workers was subject to negative changes as compared to the analysis results from those in the control group. The research results have practical value for the prophylaxis, treatment, and health resumption of the people living in rugged ecological environment and workers who are engaged with harmful substances in chemical industry. Furthermore,this research also provides recommendations for treatment of dental diseases related to common conditions of pathophysiological processes carried out by living organisms.
- MeSH
- dentin chemie MeSH
- furany * škodlivé účinky MeSH
- fyziologická kalcifikace účinky léků MeSH
- lidé MeSH
- nemoci zubů etiologie prevence a kontrola MeSH
- neutronová aktivační analýza statistika a číselné údaje MeSH
- orální zdraví MeSH
- pracovní expozice * škodlivé účinky MeSH
- sliny chemie MeSH
- stopové prvky analýza krev MeSH
- stříbro analýza krev MeSH
- vápník analýza krev MeSH
- železo analýza krev MeSH
- zinek analýza krev MeSH
- zubní cement (tkáň) chemie MeSH
- zubní sklovina chemie MeSH
- Check Tag
- lidé MeSH
The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation. In this study, the pattern of expression of c-MYB was followed during postnatal stages of mouse molar odontogenesis using immunohistochemistry on serial sections. Along with an abundance of the c-MYB protein in proliferating zones, we confirmed the presence of this protein in differentiated ameloblasts, odontoblasts, and osteoblasts. In addition, c-MYB was also found in cementoblasts and alveolar fibroblasts. These findings suggest integration of c-MYB into regulatory networks during hard-tissue differentiation and mineralization.
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- ameloblasty metabolismus MeSH
- buněčná diferenciace genetika MeSH
- buňky pojivové tkáně metabolismus MeSH
- geny myc genetika MeSH
- koncové značení zlomů DNA in situ MeSH
- moláry cytologie růst a vývoj metabolismus MeSH
- myši MeSH
- odontogeneze genetika MeSH
- processus alveolaris cytologie růst a vývoj metabolismus MeSH
- protoonkogenní proteiny c-myb * analýza genetika metabolismus MeSH
- vývoj kostí genetika fyziologie MeSH
- vývojová regulace genové exprese genetika fyziologie MeSH
- zubní cement (tkáň) metabolismus MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Not only are teeth essential for mastication, but also missing teeth are considered a social handicap due to speech and aesthetic problems, with a resulting high impact on emotional well-being. Several treatment procedures are currently available for tooth replacement with mostly inert prosthetic materials and implants. Natural tooth substitution based on copying the developmental process of tooth formation is particularly challenging and creates a rapidly developing area of molecular dentistry. In any approach, functional interactions among the tooth, the surrounding bone, and the periodontium must be established. Therefore, recent research in craniofacial genetics searches for mechanisms responsible for correct cell and tissue interactions, not only within a specific structure, but also in the context of supporting structures. A tooth crown that is not functionally anchored to roots and bone is useless. This review aims to summarize the developmental and tissue homeostatic aspects of the tooth-bone interface, from the initial patterning toward tooth eruption and lifelong interactions between the tooth and its surrounding alveolar bone.
- MeSH
- homeoboxové geny MeSH
- lidé MeSH
- odontogeneze genetika MeSH
- osteoblasty fyziologie MeSH
- osteogeneze genetika MeSH
- periodontální vaz embryologie MeSH
- processus alveolaris embryologie MeSH
- prořezávání zubů MeSH
- signální transdukce MeSH
- zubní cement (tkáň) fyziologie MeSH
- zubní kořen embryologie MeSH
- zubní korunka (anatomie) embryologie MeSH
- zubní zárodek embryologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
