Our study aimed to investigate subacute exposure to alcohol in relation to bone microstructure of mice. Animals from experimental (E) group drank a solution composed of 15 % ethanol and water for 14 days (one remodeling cycle), while those from control (C) group drank only water. In the compact bone of E group, decreased bone formation and increased porosity were observed which corresponds with lower levels of serum alkaline phosphatase and glutathione. Alcohol significantly increased sizes of primary osteon's vascular canals and decreased those of secondary osteons, Haversian canals. Relative bone volume, bone mineral density (BMD), relative bone volume without marrow cavity were also lower in E group. On the contrary, trabecular bone microstructure did not differ significantly between E and C groups. Liver function test showed higher levels of alanine aminotransferase, aspartate aminotransferase in alcohol-fed mice. Serum calcium, phosphate were significantly lower in E group. According to our study, only changes in compact bone microstructure of mice following one remodeling cycle were observed due to both direct and indirect effects of alcohol.
- MeSH
- Bone Matrix physiology MeSH
- Bone Morphogenetic Proteins metabolism MeSH
- Transglutaminases physiology MeSH
- Publication type
- Congress MeSH
- MeSH
- Models, Biological * MeSH
- Microscopy, Electron methods utilization MeSH
- Animal Experimentation MeSH
- Glycosaminoglycans * diagnostic use MeSH
- Histological Techniques methods utilization MeSH
- Hormones diagnostic use adverse effects MeSH
- Collagen physiology MeSH
- Bone and Bones anatomy & histology cytology injuries MeSH
- Bone Matrix anatomy & histology cytology physiology MeSH
- Rats MeSH
- Periosteum anatomy & histology cytology injuries MeSH
- Osteocytes * cytology physiology MeSH
- Osteology MeSH
- Connective Tissue anatomy & histology physiology MeSH
- Statistics as Topic MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
