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Autor
Aaltonen, Lauri 1 Abu-Ful, Zomoroda 1 Ahn, Yoon-Ok 1 Albanes, Demetrius 1 Arndt, Volker 1 Berndt, Sonja 1 Bien, Stephanie 1 Bishop, Timothy 1 Blackmur, James 1 Brenner, Hermann 1 Brezina, Stefanie 1 Briggs, Sarah 1 Broderick, Peter 1 Buchanan, Daniel 1 Bézieau, Stéphane 1 Böhm, Jan 1 Cai, Qiuyin 1 Cajuso, Tatiana 1 Campbell, Peter 1 Casey, Graham 1
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Pracoviště
Bioinformatics and Data Science Resea... 1 Biomedicine Institute University of L... 1 Broad Institute of Harvard and MIT Ca... 1 Broad Institute of MIT and Harvard Ca... 1 Cancer Center University of Hawaii Ho... 1 Cancer Epidemiology Division Cancer C... 1 Cancer Epidemiology Program H Lee Mof... 1 Cancer Immunology Program Dana Farber... 1 Cancer Research Institute Seoul Natio... 1 Candiolo Cancer Institute FPO IRCCS C... 1 Case Comprehensive Cancer Center Case... 1 Center for Colorectal Cancer National... 1 Center for Gastrointestinal Biology a... 1 Center for Inherited Disease Research... 1 Center for Public Health Genomics Dep... 1 Central Finland Health Care District ... 1 Centre for Epidemiology and Biostatis... 1 Centre for Global Health Usher Instit... 1 Channing Division of Network Medicine... 1 City of Hope National Medical Center ... 1
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Autor
Aaltonen, Lauri 1 Abu-Ful, Zomoroda 1 Ahn, Yoon-Ok 1 Albanes, Demetrius 1 Arndt, Volker 1 Berndt, Sonja 1 Bien, Stephanie 1 Bishop, Timothy 1 Blackmur, James 1 Brenner, Hermann 1 Brezina, Stefanie 1 Briggs, Sarah 1 Broderick, Peter 1 Buchanan, Daniel 1 Bézieau, Stéphane 1 Böhm, Jan 1 Cai, Qiuyin 1 Cajuso, Tatiana 1 Campbell, Peter 1 Casey, Graham 1
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Pracoviště
Bioinformatics and Data Science Resea... 1 Biomedicine Institute University of L... 1 Broad Institute of Harvard and MIT Ca... 1 Broad Institute of MIT and Harvard Ca... 1 Cancer Center University of Hawaii Ho... 1 Cancer Epidemiology Division Cancer C... 1 Cancer Epidemiology Program H Lee Mof... 1 Cancer Immunology Program Dana Farber... 1 Cancer Research Institute Seoul Natio... 1 Candiolo Cancer Institute FPO IRCCS C... 1 Case Comprehensive Cancer Center Case... 1 Center for Colorectal Cancer National... 1 Center for Gastrointestinal Biology a... 1 Center for Inherited Disease Research... 1 Center for Public Health Genomics Dep... 1 Central Finland Health Care District ... 1 Centre for Epidemiology and Biostatis... 1 Centre for Global Health Usher Instit... 1 Channing Division of Network Medicine... 1 City of Hope National Medical Center ... 1
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- Fernandez-Rozadilla, Ceres
- Timofeeva, Maria
- Chen, Zhishan
- Law, Philip
- Thomas, Minta
- Schmit, Stephanie
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Díez-Obrero, Virginia
Autor Díez-Obrero, Virginia Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Madrid, Spain Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
- Hsu, Li
- Fernandez-Tajes, Juan
- Palles, Claire
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 2000-01-01 do Před 1 rokem
PubMed
36539618
DOI
10.1038/s41588-022-01222-9
Knihovny.cz E-zdroje
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.
- MeSH
- celogenomová asociační studie MeSH
- Evropané * genetika MeSH
- genetická predispozice k nemoci MeSH
- jednonukleotidový polymorfismus genetika MeSH
- kolorektální nádory * genetika MeSH
- lidé MeSH
- multiomika MeSH
- východní Asiaté * genetika MeSH
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- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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